Therapeutic Application of Adiponectin in Patients with Acute Myocardial Infarction

Abstract

A therapeutic method for cardiac diseases such as angina, myocardial infarction, arrhythmia (ventricular tachycardia, ventricular fibrillation and atrial fibrillation) is provided. The method is characterized by intracoronary administration of adiponection to mammals.

1 . A therapeutic method liar cardiac diseases in mammals, the method comprising:
 a step of preparing adiponectin; and   a step of intracoronary administration of said adiponectin to mammals.   
     
     
         2 . The therapeutic method as set forth in  claim 1 , wherein the step of intracoronary administration of said adiponectin to mammals is the step of bolus intracoronary administration of adiponectin. 
     
     
         3 . The therapeutic method as set forth in  claim 1 , wherein the step of intracoronary administration of said adiponectin to mammals further comprises the step of reperfusion. 
     
     
         4 . The therapeutic method as set forth in  claim 2 , wherein the step of bolus intracoronary administration of adiponectin to mammals is performed 1 to 60 minutes after reperfusion. 
     
     
         5 . The therapeutic method as set forth in  claim 1 , wherein a dosage of said adiponectin is in the range of 0.01 μg/kg to 10 μg/kg. 
     
     
         6 . The therapeutic method as set forth in  claim 1 , wherein said cardiac disease is acute myocardial infarction. 
     
     
         7 . The therapeutic method as set forth in  claim 1 , wherein said mammals are humans. 
     
     
         8 . A pharmacological composition comprising a therapeutically effective amount of adiponectin as active ingredient with one or more pharmaceutically acceptable diluents, excipients, and/or an inert carrier.