Oligosaccharide aldonic acids and their topical use

Abstract

Methods for using compositions comprising oligosaccharide aldonic acids for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and/or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Methods may comprise using compositions comprising oligosaccharide aldonic acids and additional cosmetic, pharmaceutical or other topical agents to enhance or create synergetic effects.

We claim: 
     
         1 . A method for the treatment of cosmetic conditions or dermatological disorders comprising topically applying to a subject in need thereof a composition comprising a therapeutically effective amount of lactobionic acid as free acid, ester, salt, partial salt, lactone, stereoisomeric, non-stereoisomeric, saturated or unsaturated, straight or branched chain, or cyclic form thereof, wherein the cosmetic condition or dermatological disorder is selected from the group of indications consisting of ichthyosis; uneven and rough surface of skin; lichen simplex chronicus; pseudofolliculitis barbae; eczema; psoriasis; pruritus; wound-healing and treatment of skin wounds; general care as well as treatment of diseases and conditions of oral, gum, and vaginal and anal mucosa. 
     
     
         2 . The method of  claim 1 , wherein the cosmetic condition or dermatological disorder is selected from the group of indications consisting of eczema, psoriasis, and pseudofolliculitis barbae. 
     
     
         3 . The method of  claim 2 , wherein the cosmetic condition or dermatological disorder is selected from eczema or pseudofolliculitis barbae. 
     
     
         4 . The method of  claim 2 , wherein the cosmetic condition or dermatological disorder is pseudofolliculitis barbae. 
     
     
         5 . The method of  claim 2 , wherein the cosmetic condition or dermatological disorder is eczema. 
     
     
         6 . The method of  claim 1 , wherein the cosmetic condition or dermatological disorder is uneven and rough surface of skin. 
     
     
         7 . The method of  claim 1 , wherein the composition further comprises a topically active agent selected from the group consisting of local analgesics and anesthetics; antibacterial agents; antiyeast agents; antifungal agents; antiviral agents; antidandruff agents; antidermatitis agents; antihistamine agents; antipruritic agents; antiemetics; antimotion sickness agents; antiinflammatory agents; antihyperkeratotic agents; antiperspirants; antipsoriatic agents; antiseborrheic agents; vitamins; corticosteroids; tanning agents; hormones; amino acids; dipeptides; tripeptides; oligopeptides; polypeptides; retinoids; wound healing agents; oral, vaginal and anal care or treatment agents; and gum disease treatment or care agents. 
     
     
         8 . The method of  claim 7 , wherein the topically active agent is selected from the group consisting of aclovate, acyclovir, adapalene, albuterol, aluminum acetate, aluminum chloride, aluminum hydroxide, aluminum chlorohydroxide, amantadine, aminacrine, γ-aminobutanoic acid, aminocaproic acid, amitriptyline, anserine, anthralin, ascorbic acid, ascoryl palmitate, atropine, azelaic acid, bacitracin, bemegride, beclomethasone dipropionate, benzocaine, betamethasone dipropionate, betamethasone valerate, brompheniramine, bupivacaine, butoconazole, calcipotriene, camphor, capsaicin, carbamide peroxide, carnosine, chitosan, chlorhexidine, chloroxylenol, chlorpheniramine, ciclopirox, clemastine, clioquinol, clobetasol propionate, clotrimazole, coal tar, cromolyn, crotamiton, cycloserine, dehydroepiandrosterone, desoximetasone, dexamethasone, diphenhydramine, doxypin, doxylamine, dyclonine, econazole, estradiol, ethinyl estradiol, fluocinonide, fluocinolone acetonide, 5-fluorouracil, glutathione, griseofulvin, guaifenesin, haloprogin, hexylresorcinol, homocarnosine, hydrocortisone, hydrocortisone 21-acetate, hydrocortisone 17-valerate, hydrocortisone 17-butyrate, hydrogen peroxide, hydroxyzine, ibuprofen, ichthammol, imiquimod, indomethacin, ketoconazole, ketoprofen, lidocaine, meclizine, menthol, mepivacaine, methyl nicotinate, miconazole, minocycline, minoxidil, mupirocin, naftifine, naproxen, neomycin, nystatin, ophidine, ornithine, oxiconazole, oxymetazoline, permethrin, pheniramine, phenol, phenylephrine, phenylpropanolamine, piperonyl butoxide, podophyllin, podofilox, povidone iodine, polymyxins, pramoxine, prilocaine, procaine, promethazine propionate, propranolol, pseudoephedrine, pyrethrin, pyrilamine, resorcinol, retinol, retinyl acetate, retinyl palmitate, salicylamide, selenium sulfide, shale tar, sulconazole, sulfur, sulfadiazine, tazarotene, terbinafine, terconazole, tetracaine, tetrahydrozoline, thymol, tioconazole, tolnaftate, triamcinolone diacetate, triamcinolone acetonide, triamcinolone hexacetonide, triclosan, triprolidine, undecylenic acid, urea, vitamin E acetate, wood tar, and zinc pyrithione.