US2012041180A1PendingUtilityA1

Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses

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Assignee: SHEFFER JOSEPHPriority: Sep 8, 2006Filed: Jul 18, 2011Published: Feb 16, 2012
Est. expirySep 8, 2026(~0.2 yrs left)· nominal 20-yr term from priority
Inventors:Joseph ShefferThea NormanRichard D. DimarchiAnna-Maria A. Hays PutnamFeng TianStephanie ChuDenise KrawitzHo Sung Cho
C07K 2319/00C07K 14/47C07K 14/62C07K 14/765C07K 19/00A61K 38/00C07K 14/575A61P 43/00C07K 14/435A61K 38/17A61P 7/00
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Abstract

Modified human plasma polypeptides or Fc and uses thereof are provided.

Claims

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1 - 76 . (canceled) 
     
     
         77 . A human serum albumin (HSA) comprising a non-naturally encoded amino acid at one of the following positions: 34, 82, 172, 301, 364, and 505 of SEQ ID NO: 1 linked to coagulation factor VIII.

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