US2012046242A1PendingUtilityA1

Molecular activators of the wnt/beta-catenin pathway

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Assignee: MOON RANDALL TPriority: Dec 24, 2008Filed: Dec 21, 2009Published: Feb 23, 2012
Est. expiryDec 24, 2028(~2.4 yrs left)· nominal 20-yr term from priority
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Claims

Abstract

The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject a compound selected from the group consisting of those set forth in Table 1, Table 2, and a pharmaceutically acceptable salt thereof. A method of similarly modulating the Wnt/β-catenin pathway in a subject is also discussed.

Claims

exact text as granted — not AI-modified
1 . A method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling, said method comprising:
 selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject a compound selected from the group consisting of those set forth in Table 1 or Table 2, and a pharmaceutically acceptable salt thereof. 
 
     
     
         2 . The method of  claim 1 , wherein the subject is human. 
     
     
         3 . The method of  claim 1 , wherein a compound of Table 1 or a pharmaceutically acceptable salt thereof is administered. 
     
     
         4 . The method of  claim 1 , wherein a compound of Table 2 or a pharmaceutically acceptable salt thereof is administered. 
     
     
         5 . (canceled) 
     
     
         6 . A method of activating the Wnt/β-catenin pathway in a subject comprising:
 selecting a subject in need of Wnt/β-catenin pathway activating and 
 administering to the selected subject a compound selected from the group consisting of those set forth in Table 1 or Table 2, and a pharmaceutically acceptable salt thereof. 
 
     
     
         7 . The method of  claim 6 , wherein a compound of Table 1 or a pharmaceutically acceptable salt thereof is administered. 
     
     
         8 . The method of  claim 6 , wherein a compound of Table 2 or a pharmaceutically acceptable salt thereof is administered.

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