Methods, compositions and devices for inducing stasis in tissues and organs

Abstract

The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes is provided.

1 - 130 . (canceled) 
     
     
         131 . A method for inducing growth in integumentary tissue comprising:
 a) isolating integumentary tissue; and   b) exposing the tissue to an oxygen antagonist, wherein the oxygen antagonist is carbon monoxide; thereby inducing growth in integumentary tissue.   
     
     
         132 . The method of  claim 131 , wherein the effective amount is a sublethal dose of the oxygen antagonist. 
     
     
         133 . The method of  claim 131 , wherein the oxygen antagonist is a gas, semi-solid liquid, or liquid. 
     
     
         134 . The method of  claim 133 , wherein the oxygen antagonist is a gas. 
     
     
         135 . The method of  claim 131 , further comprising subjecting the tissue to a controlled temperature environment. 
     
     
         136 . The method of  claim 135 , further comprising modulating environmental oxygen levels or removing the tissue from an environment having oxygen. 
     
     
         137 . The method of  claim 131 , further comprising assessing the level of the oxygen antagonist and/or oxidative phosphorylation in the tissue. 
     
     
         138 . The method of  claim 131 , further comprising removing the oxygen antagonist. 
     
     
         139 . The method of  claim 131 , further comprising placing the tissue under a vacuum. 
     
     
         140 . The method of  claim 131 , wherein the tissue is damaged.