Parakeratosis inhibitor and skin preparation for external use

Abstract

To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives. Further, there are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

What is claimed is: 
     
         1 . A parakeratosis inhibitor agent or a pore-shrinking agent comprising one or two or more compounds selected from a group consisting of benzoylaminodicarbonic acid derivatives or benzenesulfonylaminodicarbonic acid derivatives, as well as the salts of the derivatives as represented by general formula (2): 
       
         
           
           
               
               
           
         
       
       where in the above formula (2), X 1 , X 2 , X 3  are respectively and independently a hydrogen atom, an alkyl group having 1 to 4 carbons, an alkoxyl group having 1 to 4 carbons, a hydroxyl group, an amino group, an alkylamino group having 1 to 4 carbons, a chlorine atom, a bromine atom, a fluorine atom, or a trifluoromethyl group, and Z represents a carbonyl group or a sulfonyl group, where n is 1 or 2. 
     
     
         2 . A parakeratosis inhibiting skin preparation for external use comprising a parakeratosis inhibitor agent in accordance with  claim 1 . 
     
     
         3 . A pore-shrinking skin preparation for external use comprising a pore-shrinking agent in accordance with  claim 1 . 
     
     
         4 . A method of using one or two or more compounds selected from a group consisting of benzoylaminodicarbonic acid derivatives or benzenesulfonylaminodicarbonic acid derivatives, as well as the salts of the derivatives as represented by general formula (2) in order to inhibit parakeratosis: 
       
         
           
           
               
               
           
         
       
       where in the above formula (2), X 1 , X 2 , X 3  are respectively and independently a hydrogen atom, an alkyl group having 1 to 4 carbons, an alkoxyl group having 1 to 4 carbons, a hydroxyl group, an amino group, an alkylamino group having 1 to 4 carbons, a chlorine atom, a bromine atom, a fluorine atom, or a trifluoromethyl group, and Z represents a carbonyl group or a sulfonyl group, where n is 1 or 2. 
     
     
         5 . A method of using one or two or more compounds selected from a group consisting of benzoylaminodicarbonic acid derivatives or benzenesulfonylaminodicarbonic acid derivatives, as well as the salts of the derivatives as represented by general formula (2) in order to shrink a skin pore: 
       
         
           
           
               
               
           
         
       
       where in the above formula (2), X 1 , X 2 , X 3  are respectively and independently a hydrogen atom, an alkyl group having 1 to 4 carbons, an alkoxyl group having 1 to 4 carbons, a hydroxyl group, an amino group, an alkylamino group having 1 to 4 carbons, a chlorine atom, a bromine atom, a fluorine atom, or a trifluoromethyl group, and Z represents a carbonyl group or a sulfonyl group, where n is 1 or 2. 
     
     
         6 . A parakeratosis inhibitor agent, pore-shrinking agent, or skin roughness preventing/ameliorating agent comprising one or two or more compounds selected from a group consisting of aminosulfuric acid derivatives and the salts thereof as represented by general formula (9) or (10): 
       
         
           
           
               
               
           
         
       
       where in the above general formula (10), R 7  represents a hydrogen atom or a hydroxyl group. 
     
     
         7 . A parakeratosis inhibiting skin preparation for external use comprising a parakeratosis inhibitor agent in accordance with  claim 6 . 
     
     
         8 . A pore-shrinking skin preparation for external use comprising a pore-shrinking agent in accordance with  claim 6 . 
     
     
         9 . A skin roughness preventing/ameliorating skin preparation for external use comprising a skin roughness preventing/ameliorating agent in accordance with  claim 6 . 
     
     
         10 . A method of using one or two or more compounds selected from a group consisting of aminosulfuric acid derivatives and the salts thereof as represented by general formula (9) or (10) to inhibit parakeratosis: 
       
         
           
           
               
               
           
         
       
       where in the above general formula (10), R 7  represents a hydrogen atom or a hydroxyl group. 
     
     
         11 . A method of using one or two or more compounds selected from a group consisting of aminosulfuric acid derivatives and the salts thereof as represented by general formula (9) or (10) to shrink a skin pore: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       where in the above general formula (10), R 7  represents a hydrogen atom or a hydroxyl group. 
     
     
         12 . A method of using one or two or more compounds selected from a group consisting of aminosulfuric acid derivatives and the salts thereof as represented by general formula (9) or (10) to prevent/ameliorate skin roughness: 
       
         
           
           
               
               
           
         
       
       where in the above general formula (10), R 7  represents a hydrogen atom or a hydroxyl group.