Non-sedating antihistamine injection formulations and methods of use thereof

Abstract

Described herein are automatic injectors suitable for administration of a non-sedating antihistamine, and methods of using the automatic injectors. A specific non-sedating antihistamine is cetirizine. The automatic injectors are useful in treating acute urticaria or angioedema associated with an acute allergic reaction including anaphylaxis.

1 . A method of treating acute urticaria or angioedema associated with an acute allergic reaction including anaphylaxis in an individual in need thereof, comprising
 self-administering from an automatic injector a pre-measured dose of a non-sedating antihistamine composition subcutaneously or intramuscularly,   wherein the non-sedating antihistamine composition comprises a non-sedating antihistamine and a pH adjusting agent and has a pH of 3 to 9, wherein the non-sedating antihistamine comprises cetirizine or a salt thereof,   wherein the automatic injector comprises a housing comprising a chamber for the non-sedating antihistamine composition and a dispensing assembly in communication with the chamber.   
     
     
         2 . The method of  claim 1 , wherein the non-sedating antihistamine composition further comprises ranitidine, cimetidine, epinephrine, methylprednisolone, prednisolone, or a combination thereof. 
     
     
         3 . The method of  claim 1 , further comprising self-administering from a second automatic injector an epinephrine composition, wherein the second automatic injector comprises a second housing comprising a second chamber for the epinephrine composition and a second dispensing assembly in communication with the second chamber. 
     
     
         4 . The method of  claim 1 , wherein treating is in an emergency situation. 
     
     
         5 . The method of  claim 1 , wherein self-administering the non-sedating antihistamine from the automatic injector is non-cardiotoxic and non-sedating. 
     
     
         6 . An automatic injector for self-administration of a pre-measured dose of a non-sedating antihistamine composition subcutaneously or intramuscularly, comprising
 a housing comprising a chamber for the non-sedating antihistamine composition and a dispensing assembly in communication with the chamber,   wherein the non-sedating antihistamine composition comprises a non-sedating antihistamine and a pH adjusting agent and has a pH of 3 to 9, wherein the non-sedating antihistamine comprises cetirizine or a salt thereof.   
     
     
         7 . The automatic injector of  claim 6 , wherein the non-sedating antihistamine composition further comprises ranitidine, cimetidine, epinephrine, methylprednisolone, prednisolone, or a combination thereof. 
     
     
         8 . A kit comprising the automatic injector comprising a non-sedating antihistamine composition of  claim 6 , and a second automatic injector comprising a second housing comprising a second chamber for an epinephrine composition and a second dispensing assembly in communication with the second chamber.