Hemostatic compositions and methods of making and using same

Abstract

The disclosure pertains to hemostatic compositions comprising a plurality of nonwoven fibers disposed in a rapidly soluble solid matrix and methods of making and using the same. The compositions may also comprise one or more therapeutic agents.

What is claimed is: 
     
         1 . A hemostatic composition comprising:
 a plurality of nonwoven fibers;   a rapidly soluble solid matrix; and   one or more therapeutic agents.   
     
     
         2 . The hemostatic composition of  claim 1 , wherein the plurality of nonwoven fibers each are greater than about 50 nanometers in diameter and less than about 20 microns in diameter. 
     
     
         3 . The hemostatic composition of  claim 1 , wherein the nonwoven fibers comprise a polysaccharide. 
     
     
         4 . The hemostatic composition of  claim 3 , wherein the polysaccharide is a non-cellulosic polysaccharide. 
     
     
         5 . The hemostatic composition of  claim 3 , wherein the polysaccharide is hyaluronic acid or a derivative thereof. 
     
     
         6 . The hemostatic composition of  claim 3 , wherein the polysaccharide is pectin or acetylated pectin. 
     
     
         7 . The hemostatic composition of  claim 3 , wherein the polysaccharide comprises hyaluronic acid, or a derivative thereof, and pectin or acetylated pectin. 
     
     
         8 . The hemostatic composition of  claim 1 , wherein the rapidly soluble solid matrix is a liquid at body temperature. 
     
     
         9 . The hemostatic composition of  claim 8 , wherein the rapidly soluble solid matrix comprises ice. 
     
     
         10 . The hemostatic composition of  claim 1 , wherein the rapidly soluble solid matrix comprises a sugar. 
     
     
         11 . The hemostatic composition of  claim 9 , wherein the sugar is dextran. 
     
     
         12 . The hemostatic composition of  claim 1 , wherein the plurality of nonwoven fibers are adapted to assume an expanded state upon release from the rapidly soluble solid matrix. 
     
     
         13 . The hemostatic composition of  claim 1 , wherein the therapeutic agent is a blood clotting agent. 
     
     
         14 . The hemostatic composition of  claim 1 , wherein the nonwoven fibers further comprise a non-polysaccharide biodegradable polymer. 
     
     
         15 . A method of forming a hemostatic composition comprising:
 providing a plurality of nonwoven fibers, said fibers comprising one or more non-cellulosic polysaccharides;   compressing the plurality of nonwoven fibers;   introducing the plurality of compressed nonwoven fibers into a mold;   introducing a rapidly soluble matrix material into the mold;   solidifying the rapidly soluble matrix material; and   removing the hemostatic composition from the mold while maintaining the rapidly soluble matrix material in a solid state.   
     
     
         16 . The method of  claim 15 , further comprising introducing one or more therapeutic agents into the mold prior to the solidifying step. 
     
     
         17 . A method of sealing a tissue puncture comprising:
 providing a hemostatic composition comprising:
 a plurality of nonwoven fibers; 
 a rapidly soluble solid matrix; and 
 one or more therapeutic agents; 
   inserting the hemostatic composition into a tissue puncture;   exposing the hemostatic composition to at least one of a body fluid or saline;   liquefying the rapidly soluble solid matrix; and   allowing the plurality of nonwoven fibers to swell, thereby occluding the tissue puncture.   
     
     
         18 . The method of  claim 17 , wherein the plurality of nonwoven fibers are greater than about 50 nanometers in diameter and less than about 20 microns in diameter. 
     
     
         19 . The method of  claim 17 , wherein the plurality of nonwoven fibers comprise a non-cellulosic polysaccharide. 
     
     
         20 . The method of  claim 17 , wherein the liquefying step releases at least a portion of the one or more therapeutic agents.