Compositions comprising cannabinoids for treatment of nausea, vomiting, emesis, motion sickness or like conditions

Abstract

Cannabinoids, in particular CBD and CBDA and their acid derivatives are provided for use as an active pharmaceutical substance in the treatment of nausea, vomiting, emesis, motion sickness. In particular extracts of cannabis plants are presented which are rich in these substances and suitable for pharmaceutical use.

We claim: 
     
         1 - 30 . (canceled) 
     
     
         31 . A pharmaceutical composition comprising cannabidiolic acid (CBDA) or cannabidiolic acid propyl variant (CBDVA). 
     
     
         32 . The composition of  claim 31 , wherein the CBDA or CBDV is in the form of a  cannabis  based medicinal extract (CBME). 
     
     
         33 . The composition of  claim 32 , wherein the CBME further comprises volatile oils. 
     
     
         34 . The composition of  claim 33 , wherein the volatile oils comprise terpenes or carotenes. 
     
     
         35 . The composition of  claim 34 , wherein the terpenes comprise C10 terpenes, and C15 terpenes. 
     
     
         36 . The composition of  claim 35 , wherein the C10 terpenes comprise myrcenes and pinenes. 
     
     
         37 . The composition of  claim 35 , wherein the C15 terpenes comprise caryophyllene. 
     
     
         38 . The composition of  claim 32 , wherein the CBME is a methanolic or sub-critical carbon dioxide (CO 2 ) extract. 
     
     
         39 . The composition of  claim 38 , wherein the sub-critical CO 2  extract is obtained under the following conditions: pressure 60 bar±10 bar and temperature 10° C.±5° C. 
     
     
         40 . The composition of  claim 39 , wherein the composition has been further purified to remove one or more of: waxes and other non-specific lipid-soluble material, water, ethanol and colour. 
     
     
         41 . The composition of  claim 32 , wherein the CBME comprises greater than 90% w/w CBDA or CBDVA relative to the other cannabinoids present, measured by HPLC with reference to tetrahydrocannabinol (acid) (THC(A)) and cannabinol (CBN). 
     
     
         42 . The composition of  claim 41  for use in the treatment of nausea, vomiting, emesis, motion sickness or like conditions.