US2012059462A1PendingUtilityA1

Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor

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Individually held — no corporate assignee on recordPriority: Nov 29, 2000Filed: Nov 15, 2011Published: Mar 8, 2012
Est. expiryNov 29, 2020(expired)· nominal 20-yr term from priority
Inventors:Vernon G. Wong
A61P 9/00A61P 43/00A61P 41/00A61P 37/06A61P 27/02A61P 27/00A61K 9/0051A61K 9/1641A61L 27/54A61L 2300/41A61K 31/765A61F 9/0017A61L 2300/416A61K 45/06A61K 9/0048A61K 9/1647A61K 31/573A61F 9/0008A61L 2300/604A61F 2210/0004A61L 2300/222A61K 31/56A61K 47/34A61K 31/715
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Claims

Abstract

Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A solid bioerodible implant for reducing or preventing transplant rejection in an eye of an individual, the implant comprising about 50% by weight of dexamethasone, about 15% by weight of hydroxypropyl methylcellulose (HPMC), and about 35% by weight of Resomer RG 502H PLGA. 
     
     
         2 . A solid bioerodible implant for reducing or preventing transplant rejection in an eye of an individual, the implant comprising about 60% by weight of dexamethasone, about 30% by weight of Resomer RG 502H PLGA, and about 10% by weight of Resomer RG 502 PLGA. 
     
     
         3 . A method for reducing or preventing transplant rejection in an eye of an individual, the method comprising:
 a) performing an ocular transplant procedure on an eye of an individual; and   b) implanting in the eye a solid bioerodible implant according to  claim 1 , thereby reducing or preventing transplant rejection.   
     
     
         4 . A method for reducing or preventing transplant rejection in an eye of an individual, the method comprising:
 a) performing an ocular transplant procedure on an eye of an individual; and   b) implanting in the eye a solid bioerodible implant according to  claim 2 , thereby reducing or preventing transplant rejection.

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