Dendrobium chysotoxum extract and its cosmetic use as an anti-aging agent

Abstract

The invention relates to a cosmetic composition comprising at least one extract from the orchid Dendrobium chrysotoxum as an active agent and at least one cosmetically acceptable excipient. The invention relates to the use in a cosmetic composition of an extract from the orchid Dendrobium chrysotoxum as an active agent for preventing or delaying the appearance of the signs of skin ageing or for slowing or attenuating the effects thereof, or else also for promoting cell or tissue longevity. The invention in particular relates to an orchid extract inhibiting the expression and/or the activity of the mitochondrial protein Smac/DIABLO.

1 . Cosmetic composition comprising at least one extract of flowers of the orchid  Dendrobium chrysotoxum  as an active agent and at least one cosmetically acceptable excipient. 
     
     
         2 . Cosmetic composition according to  claim 1 , wherein said extract inhibits the expression and/or the activity of the mitochondrial protein Smac/DIABLO. 
     
     
         3 . Cosmetic composition according to  claim 1 , wherein said extract is obtained by means of a polar solvent or a mixture of polar solvents, advantageously selected from water, a C 1 -C 4  alcohol, preferably ethanol, a C 2 -C 6  glycol, preferably selected from glycerol, butylene glycol and propylene glycol, or else also any mixture thereof. 
     
     
         4 . Cosmetic composition according to  claim 1 , wherein said extract is obtained by means of a solvent comprising at least 50% v/v of ethanol and up to 100% v/v of ethanol, the balance if necessary consisting of another polar solvent and in particular of water. 
     
     
         5 . Cosmetic composition according to  claim 1 , wherein it comprises from 0.0001% to 1% by weight of dry extract, preferably from 0.001% to 0.01% by weight of dry extract relative to the total weight of the composition. 
     
     
         6 . Cosmetic composition according to  claim 1 , wherein it comprises a combination of the extract of flowers of the orchid  Dendrobium chrysotoxum  with other cosmetically acceptable active agents, in the form of purified substances and/or extracts, in particular plant extracts. 
     
     
         7 . Cosmetic composition according to  claim 1 , wherein it comprises at least one extract of another part of the orchid  Dendrobium chrysotoxum  or of another orchid or a substance purified from such an extract. 
     
     
         8 . Cosmetic composition according to  claim 1 , wherein it comprises one or more other active agents among those which stimulate the expression and/or the activity of survivin such as forskolin or an extract containing these, in particular an extract of  Coleus forskolii , or else also a plant extract obtained from a plant species selected from  Nostoc commune, Butea frondosa, Neochloris oleabundans, Scenedesmus dimorphus, Curcuma longa, Crocus sativus, Daniellia oliveri; Lepechinia caulescens, Limnophila conferta , and any mixture thereof. 
     
     
         9 . Cosmetic composition according to  claim 1 , wherein the acceptable cosmetic excipient is chosen among pigments, colorants, polymers, surfactants, rheological agents, perfumes, electrolytes, pH adjusters, antioxidant agents, preservatives and any one of their mixtures. 
     
     
         10 . Use of at least one extract of flowers of the orchid  Dendrobium chrysotoxum , in a cosmetic composition, as an active agent intended to prevent or delay the appearance of the signs of skin ageing or to slow or attenuate the effects thereof, or else also to promote cell or tissue longevity. 
     
     
         11 . Use according to  claim 10 , wherein the composition is itself intended to prevent or delay the appearance of the signs of skin ageing or to slow or attenuate the effects thereof, or else also to promote cell or tissue longevity. 
     
     
         12 . A method of treatment for preventing or delaying the appearance of the signs of skin ageing or for slowing or attenuating the effects thereof, or else also for promoting cell or tissue longevity, comprising applying onto at least one part of the skin of the face or the body of a subject in need thereof, an effective amount of a composition according to  claim 1 . 
     
     
         13 . A method of treatment according to  claim 12 , wherein said cosmetic composition is applied onto a skin zone of the body or the face exhibiting visible signs of ageing such as the presence of wrinkles or small wrinkles or a loss of lustre of the skin complexion, or other signs such as a loss of elasticity and/or suppleness of the skin, a decrease in the thickness of the skin, and/or an increase in skin dryness or roughness. 
     
     
         14 . Orchid flower extract, in particular of the species  Dendrobium chrysotoxum , inhibiting the expression and/or the activity of the mitochondrial protein Smac/DIABLO. 
     
     
         15 . Orchid extract according to  claim 14 , wherein said extract is obtained by means of a polar solvent or a mixture of polar solvents.