Method of preparing dry powder inhalation compositions

Abstract

The invention provides a method of preparing a dry powder inhalation composition comprising a pharmaceutically acceptable particulate carrier, a first particulate inhalant medicament and a second particulate inhalant medicament. Also provided are dry powder compositions and methods of using them with a dry powder inhalation device.

1 . A method of preparing a dry powder inhalation composition comprising the steps of:
 (a) mixing a carrier with a first portion of a first particulate inhalant medicament to form an first mixture;   (b) mixing said first mixture with a second particulate inhalant medicament to form a second mixture; and   (c) mixing said second mixture with a second portion of the first particulate inhalant medicament to form a dry powder inhalation composition,   wherein, in the dry powder inhalation composition from step (c) the ratio by weight of the second particulate inhalant medicament to the carrier is less than the ratio by weight of the first particulate inhalant medicament to the carrier.   
     
     
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