US2012065385A1PendingUtilityA1
Dendritic cell co-stimulatory molecules
Est. expiryApr 28, 2020(expired)· nominal 20-yr term from priority
C07K 2319/30A61P 35/00C07K 2319/00A61K 2039/505A61K 2039/57A61P 37/04A61K 38/00A61P 37/02A61K 39/39558C07K 14/70532C07K 16/2827A61K 2039/55516A61P 37/06A61K 40/46A61K 40/32A61K 40/11A61K 2239/38A61P 31/00C12N 15/11
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Abstract
A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefore and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
Claims
exact text as granted — not AI-modified1 . An isolated nucleic acid molecule that encodes a mammalian protein termed B7-DC that is selectively expressed on dendritic cells as compared to activated macrophages.
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