Adhesive Laminates for Rapid Wound Occlusion

Abstract

Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.

What is claimed is: 
     
         1 . A dispenser for an adhesive tape, comprising:
 a biocompatible non-adherent substance;   a means to dispense an adhesive layer onto a layer of said biocompatible non-adherent substance;   a means to cut said combined layers; and   a housing having an opening.   
     
     
         2 . The dispenser of  claim 1 , wherein said biocompatible non-adherent substance dissolves upon contact with a fluid. 
     
     
         3 . The dispenser of  claim 1 , wherein one or more layers of said biocompatible non-adherent substance comprises a hydrocolloid. 
     
     
         4 . The dispenser of  claim 1 , wherein the layer of said biocompatible non-adherent substance further comprises an emulsifying agent, a solubilizing agent, a wetting agent, a taste modifying agent, a plasticizer, a bioactive agent, a water soluble inert filler, a preservative, a buffering agent, a coloring agent, a stabilizer, or a combination thereof. 
     
     
         5 . The dispenser of  claim 1 , wherein said adhesive is cyanoacrylate or a derivative thereof, a protein or a synthetic polymer. 
     
     
         6 . The dispenser of  claim 1 , wherein the means to dispense said adhesive comprises a brush impregnated with said adhesive. 
     
     
         7 . The dispenser of  claim 1 , wherein the means to dispense said adhesive comprises:
 a brush; and   an ampoule to contain said adhesive fluidly connected to said brush.   
     
     
         8 . A method of forming an adhesive tape to join one or more tissues, comprising:
 withdrawing a length of the layer of said biocompatible non-adherent substance through the opening in the dispensor of  claim 1 ;   simultaneously dispensing the adhesive layer along the length of the layer of said biocompatible non-adherent substance via the brush in said dispensor; and   cutting the combined layers via the cutting means comprising said dispenser after sufficient length has been withdrawn thereby forming said adhesive tape.   
     
     
         9 . The method of  claim 8 , further comprising:
 positioning said adhesive tape on one or more tissues, said adhesive layer in contact with said tissue(s); and   setting said adhesive thereby joining said tissue(s).