2alpha-Methyl-19-Nor-(20S)-1alpha-Hydroxy-Bishomopregnacalciferol and Its Uses

Abstract

This invention discloses 2α-methyl-19-nor-(20S)-vitamin D analogs, and specifically 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.

1 - 79 . (canceled) 
     
     
         80 . A method of treating acne comprising administering to a subject with acne an effective amount of a compound having the formula 
       
         
           
           
               
               
           
         
       
       where X 1  and X 2 , which may be the same or different, are each selected from hydrogen or a hydroxy-protecting group. 
     
     
         81 . The method of  claim 80  wherein the compound is administered orally. 
     
     
         82 . The method of  claim 80  wherein the compound is administered parenterally. 
     
     
         83 . The method of  claim 80  wherein the compound is administered transdermally. 
     
     
         84 . The method of  claim 80  wherein the compound is administered rectally. 
     
     
         85 . The method of  claim 80  wherein the compound is administered nasally. 
     
     
         86 . The method of  claim 80  wherein the compound is administered sublingually. 
     
     
         87 . The method of  claim 80  wherein the compound is administered in a dosage of from about 0.01 μg/day to about 1000 μg/day. 
     
     
         88 . The method of  claim 80  wherein the compound has the formula: 
       
         
           
           
               
               
           
         
       
       and is named is 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol.