Use of piperidine derivatives as dermo-decontracting agents

Abstract

The present invention relates to a cosmetic process for treating wrinkled skin, in particular the skin of the face and/or of the forehead, through a dermo-decontracting effect, comprising the topical application to said skin of a composition comprising, in a physiologically acceptable medium, at least one piperidine derivative chosen from the compounds of formula (I): These compounds make it possible to combat expression wrinkles according to a mechanism of dermo-decontraction.

1 . Cosmetic process for treating wrinkled skin, in particular the skin of the face and/or of the forehead, through a dermo-decontracting effect, comprising the topical application to said skin of a composition comprising, in a physiologically acceptable medium, at least one piperidine derivative chosen from the compounds of formula (I): 
       
         
           
           
               
               
           
         
       
       in which:
 R 1  denotes a halogen or a radical chosen from: a C 1 -C 6  alkyl radical, an OR group, an NRR′ group, a CF 3  group, an NHCOR group or a CONRR′ group; 
 R 2  denotes a linear or branched C 1 -C 20  alkyl or alkenyl radical optionally substituted with at least one OR, COOR, ═O, NRR′, NHCOR or CONRR′ group or with a phenyl group optionally substituted with one or more radicals R 1 ; 
 where R and R′ denote, independently of one another, a hydrogen atom or a C 1 -C 6  alkyl radical, 
 m ranges from 0 to 5; 
 n ranges from 0 to 5; 
 and their salts and optical isomers. 
 
     
     
         2 . Process according to  claim 1 , characterized in that said salt is a salt obtained by addition of the compound of formula (I) with an inorganic acid chosen from hydrochloric acid, sulphuric acid and phosphoric acid. 
     
     
         3 . Process according to  claim 1 , characterized in that said salt is a salt obtained by addition of the compound of formula (I) with an organic acid chosen from acetic acid, propionic acid, succinic acid, fumaric acid, maleic acid, lactic acid, glycolic acid, citric acid and tartaric acid. 
     
     
         4 . Process according to any one of  claims 1  to  3 , characterized in that said derivative is such that m ranges from 0 to 3. 
     
     
         5 . Process according to any one of  claims 1  to  4 , characterized in that said derivative is such that R 1  denotes a methoxy or trifluoromethyl radical. 
     
     
         6 . Process according to  claim 4 , characterized in that said derivative is such that m is equal to 0. 
     
     
         7 . Process according to any one of  claims 1  to  6 , characterized in that said derivative is such that R 2  denotes a linear or branched C 1 -C 6  alkyl or alkenyl radical optionally substituted with a phenyl group. 
     
     
         8 . Process according to any one of  claims 1  to  7 , characterized in that said derivative is such that n is equal to 0. 
     
     
         9 . Process according to any one of  claims 1  to  8 , characterized in that said derivative is 4-phenyl-1-(4-phenylbutyl)piperidine or one of its salts. 
     
     
         10 . Process according to  claim 9 , characterized in that said derivative is the maleic acid salt of 4-phenyl-1-(4-phenylbutyl)piperidine. 
     
     
         11 . Process according to any one of  claims 1  to  7 , characterized in that said derivative is such that n is equal to 1. 
     
     
         12 . Process according to  claim 11 , characterized in that said derivative is 4-benzyl-1-hexylpiperidine. 
     
     
         13 . Process according to any one of  claims 1  to  12 , characterized in that the composition is applied to the areas of the face and/or of the forehead that are marked with expression wrinkles, and/or on individuals with expression wrinkles. 
     
     
         14 . Cosmetic use of at least one piperidine derivative as defined in any one of  claims 1  to  12 , as a dermo-decontracting agent for combating wrinkles, in particular expression wrinkles, and/or for decontracting the skin and/or relaxing the features.