Composition and Method for Arresting Blood Flow and for Forming a Persistent Microbial Barrier

Abstract

A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa.

1 . A composition useful in promoting healing of a bleeding wound site comprising:
 a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms.   
     
     
         2 . The composition of  claim 1 , wherein:
 said resin providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids.   
     
     
         3 . The composition of  claim 1 , wherein:
 said resin is a hydrogen form of a sulfonated 2% crosslinked polystyrene resin.   
     
     
         4 . The composition of  claim 1 , wherein:
 said resin has a concentration of at least 26 mg/ml to provide a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa.   
     
     
         5 . A composition for providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms comprising:
 a substantially anhydrous hydrogen form of a cation exchange resin which when applied over blood from a wound, releases acidic protons from exchange with cations present in the blood, serum or exudates.   
     
     
         6 . The composition of  claim 5 , wherein:
 said resin providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids.   
     
     
         7 . The composition of  claim 6 , wherein:
 said resin is a hydrogen form of a sulfonated 2% crosslinked polystyrene resin.   
     
     
         8 . The composition of  claim 7 , wherein:
 said resin has a concentration of at least 26 mg/ml to provide a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa.   
     
     
         9 . A method for providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms associated with an open wound comprising the steps of:
 applying a substantially anhydrous hydrogen form of a cation exchange resin over blood from the wound which releases acidic protons from exchange with cations present in the blood, serum or exudates;   said resin providing dehydration and ion exchange with cations present in the blood and other body fluids;   said resin being a hydrogen form of a sulfonated crosslinked polystyrene resin;   said resin having a concentration of at least 26 mg/ml to provide a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa.