Small Peptides And Methods For Treatment Of Chronic Inflammatory Bowel Disease

Abstract

Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.

1 . A method for treating chronic inflammatory bowel disease in a patient, said method comprising administering to said patient an anti-inflammatory effective amount of a peptide or salt thereof, said peptide having the formula f-Met-Leu-X, wherein X is at lease one member selected from the group consisting of Tyr, Tyr-Phe (SEQ ID NO: 1), Phe-Phe (SEQ ID NO: 2) and Phe-Tyr (SEQ ID NO: 3). 
     
     
         2 . The method of  claim 1 , wherein an additional active ingredient is administered with said peptide, said active ingredient being selected from the group consisting of anti-leukotrienes, β 2  agonists and corticosteroids.