Computerized method and system for inferring genetic findings for a patient

Abstract

A method and system in a computing environment for preventing atypical clinical events associated with clinical agent administration to a person is provided. Clinical agent information is received. A data structure is accessed to determine if genetic findings are known to be associated with atypical events for the clinical agent. An electronic medical record is accessed to determine if a person has a stored genetic test result value for the genetic finding. Upon determining that the person does not have a stored genetic test result value, a population genetics inference based solely on demographic information is calculated indicating a likelihood the person has the genetic finding. An output is generated that includes a risk associated with atypical events for the clinical agent; the risk is based solely on the population genetics inference.

1 . A method, implemented by a server, for preventing atypical clinical events associated with clinical agent administration to a person, the method comprising:
 receiving clinical agent information, the clinical agent information including an identifier of the clinical agent;   accessing a data structure to determine if a genetic finding is known to be associated with one or more atypical clinical events for the clinical agent;   upon determining that a genetic finding is known to be associated with one or more atypical clinical events for the clinical agent, accessing the person's electronic medical record (EMR) to determine if the person has a stored genetic test result value for the genetic finding;   upon determining that the person does not have a stored genetic test result value for the genetic finding, accessing demographic information for the person to calculate a population genetics inference, the population genetics inference indicating a likelihood the person has the genetic finding; and   generating an output including a risk associated with the one or more atypical clinical events for the clinical agent, the risk based solely on the population genetics inference.   
     
     
         2 . The method of  claim 1 , wherein the clinical agent information is received via an electronic order from a clinician. 
     
     
         3 . The method of  claim 1 , wherein the data structure comprises a listing of a plurality of genetic findings associated with a plurality of clinical agents and atypical clinical events. 
     
     
         4 . The method of  claim 1 , wherein the demographic information for the person comprises gender information, ethnic information, and geographic distribution information. 
     
     
         5 . The method of  claim 1 , wherein accessing the demographic information comprises accessing the demographic information from the EMR of the person, the EMR stored within a comprehensive healthcare system. 
     
     
         6 . The method of  claim 1 , further comprising:
 automatically initiating a clinical action upon identifying a high likelihood the person has the genetic finding.   
     
     
         7 . The method of  claim 6 , wherein the clinical action comprises at least one of the following:
 (A) storing the risk associated with the one or more atypical clinical events for the clinical agent in associations with the patient's EMR,   (B) presenting a list of alternative clinical agents, or   (C) delaying or canceling the administration of the clinical agent.   
     
     
         8 . A computer system for preventing atypical clinical events associated with clinical agent administration to a person, the computer system comprising a processing unit couple to a computer-storage medium, the computer-storage medium having stored thereon a plurality of computer software components executable by the processing unit, the computer software components comprising:
 a receiving component that receives clinical agent information, the clinical agent information including an identifier of the agent;   a first accessing component that accesses a data structure to determine if a genetic finding is known to be associated with one or more atypical clinical events for the clinical agent information;   an inquiring component that inquires if the person has a stored genetic test result value for the genetic finding;   a second accessing component for accessing demographic information for the person to determine a population genetics inference;   a calculating component that calculates the population genetics inference, the population genetics inference indicating a likelihood the person has the genetic finding; and   a generating component that generates an output including a risk associated with the one or more atypical clinical events for the clinical agent information, the risk based solely on the population genetics inference.   
     
     
         9 . The system of  claim 8 , further comprising:
 a notification component that communicates a message to a clinician of the risk associated with the one or more atypical clinical events for the clinical agent information, the message communicated via alphanumeric page or electronic mail.   
     
     
         10 . The system of  claim 9 , wherein the notification component further communicates a message indicating that the risk was based solely on the population genetics inference. 
     
     
         11 . The system of  claim 8 , further comprising:
 an initiating component that initiates a clinical action upon identifying a high likelihood the person has the genetic finding.   
     
     
         12 . The system of  claim 11 , wherein the clinical action is the automatic ordering of a genetic test. 
     
     
         13 . The system of  claim 8 , wherein the demographic information comprises gender information, ethnic information, and geographic distribution information. 
     
     
         14 . A computer-readable medium, residing on computer-executable instructions that, when executed by a processing unit, perform a method for preventing atypical clinical events associated with clinical agent administration to a person, the method comprising:
 receiving clinical agent information, the clinical agent information including an identifier of the clinical agent;   accessing a data structure to determine if a genetic finding is known to be associated with one or more atypical clinical events for the clinical agent information;   upon determining that a genetic finding is known to be associated with one or more atypical clinical events for the clinical agent information, accessing the person's electronic medical record (EMR) to determine if the person has a stored genetic test result value for the genetic finding;   upon determining that the person does not have a stored genetic test result value for the genetic finding, accessing demographic information for the person to calculate a population genetics inference, the population genetics inference indicating a likelihood the person has the genetic finding; and   generating an output including a risk associated with the one or more atypical clinical events for the clinical agent information, the risk based solely on the population genetics inference.   
     
     
         15 . The method of  claim 14 , wherein the clinical agent information is received via an electronic order from a clinician. 
     
     
         16 . The method of  claim 14 , wherein the data structure comprises a listing of a plurality of genetic findings associated with a plurality of clinical agents and atypical clinical events. 
     
     
         17 . The method of  claim 14 , wherein the demographic information for the person comprises gender information, ethnic information, and geographic distribution information. 
     
     
         18 . The method of  claim 14 , wherein accessing the demographic information for the person comprises accessing the demographic information from the EMR of the person, the EMR stored within a comprehensive healthcare system. 
     
     
         19 . The method of  claim 14 , further comprising:
 automatically initiating a clinical action upon identifying a high likelihood the person has the genetic finding.   
     
     
         20 . The method of  claim 19 , wherein the clinical action comprises at least one of the following:
 (A) storing the risk associated with the one or more atypical events for the clinical agent information in association with the person's EMR,   (B) presenting a list of alternative clinical agents,   (C) delaying or canceling the administration of the clinical agent, or   (D) automatically ordering a genetic test for the person.