Methods and Compositions for the Treatment of Gastrointestinal Disorders

Abstract

Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.

1 - 52 . (canceled) 
     
     
         53 . A method for treating a patient suffering from a gastrointestinal disorder selected from the group consisting of gastroparesis and dyspepsia; the method comprising orally administering to the patient a composition comprising a polypeptide comprising the amino acid sequence Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO: 73) or Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO: 44), wherein the polypeptide activates the guanylate cyclase C receptor, thereby treating the disorder. 
     
     
         54 . The method of  claim 53 , wherein the gastrointestinal disorder is gastroparesis. 
     
     
         55 . The method of  claim 53 , wherein the gastrointestinal disorder is dyspepsia. 
     
     
         56 . The method of  claim 55 , wherein the dyspepsia is functional dyspepsia or nonulcer dyspepsia. 
     
     
         57 . The method of  claim 55 , wherein the dyspepsia is functional dyspepsia. 
     
     
         58 . A method for treating a patient suffering from a gastrointestinal disorder selected from the group consisting of gastroparesis and dyspepsia; the method comprising orally administering to the patient a composition comprising a polypeptide consisting of the amino acid sequence Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO: 73) or Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO: 44), wherein the polypeptide activates the guanylate cyclase C receptor, thereby treating the disorder. 
     
     
         59 . The method of  claim 58 , wherein the gastrointestinal disorder is gastroparesis. 
     
     
         60 . The method of  claim 58 , wherein the gastrointestinal disorder is dyspepsia. 
     
     
         61 . The method of  claim 60 , wherein the dyspepsia is functional dyspepsia or nonulcer dyspepsia. 
     
     
         62 . The method of  claim 60 , wherein the dyspepsia is functional dyspepsia.