US2012108576A1PendingUtilityA1
Thiazole compounds and methods of use
Est. expiryMay 9, 2025(expired)· nominal 20-yr term from priority
Inventors:Suoming ZhangAvinash PhadkeCuixian LiuXiangzhu WangJesse QuinnDawei ChenVenkat Rao GadhachandaShouming LiMilind Deshpande
A61P 31/20A61P 31/12C07D 487/04C07D 417/14C07D 417/06A61P 1/16C07D 277/38C07D 513/04C07D 417/04C07D 417/12C07D 277/42A61K 31/427A61K 31/426
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Claims
Abstract
The present invention provides compounds, salts and hydrates of Formula I, wherein the variables Ar 1 , R 2 , R 3 , R 4 , r, q, and t are defined herein. Certain compounds of Formula I described herein possess potent antiviral activity. The invention also provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. Certain compounds described herein inhibit assembly of the HCV replication complex. The invention also provides pharmaceutical compositions containing one or more compounds of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.
Claims
exact text as granted — not AI-modified1 .- 15 . (canceled)
16 . A compound of the formula
or pharmaceutically acceptable salt or hydrate thereof;
wherein:
Ar 1 is phenyl, naphthyl, a 5- or 6-membered monocyclic heteroaryl group, or a 9- or 10-membered bicyclic heteroaryl group, wherein Ar 1 is substituted with R and R 1 wherein there is an R 1 substituent in either the meta and para positions of the phenyl it substitutes;
R is 0 or one or more substituents independently chosen from halogen, hydroxyl, amino, cyano, nitro, C 1 -C 2 alkyl, C 1 -C 2 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy;
R 1 is one substituents chosen from C 4 -C 10 alkyl, C 4 -C 10 alkenyl, C 4 -C 10 alkynyl, C 4 -C 10 alkanoyl, C 4 -C 10 alkylester, C 4 -C 10 alkoxy, mono- and di-C 4 -C 10 alkylcarboxamide, and a group —YZ
where Y is a bond, or Y is C 1 -C 10 alkyl, a C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, each optionally having 1 or 2 oxygen or nitrogen atoms within the alkyl, alkenyl, or alkynyl chain; and
Z is C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkenyl, heterocycloalkyl, phenyl, naphthyl, indanyl, (C 3 -C 7 cycloalkyl)C 0 -C 10 alkoxy, or 5- to 6-membered heteroaryl containing 1, 2, 3, or 4 heteroatoms independently chosen from N, O, and S,
wherein each group listed in the definition of R is substituted with 0 or one or more substituents independently chosen from: halogen, hydroxyl, amino, cyano, nitro, oxo, C1-C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy;
R 2 is phenyl, a 5- to 6-membered heteroaryl, phenyl fused to a 5 or 6 membered cycloalkyl or heterocycloalkyl ring, or a bicyclic 8- to 10-membered heteroaryl, each of which is substituted with 0 or one or more substituents independently chosen from (c), (d), and (e);
(c) halogen, hydroxyl, oxo, cyano, amino, nitro, —C(O)NH 2 , —C(O)OH, —S(O)NH 2 , C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy,
(d) C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 2 -C 4 alkenyl, mono- and di-C 1 -C 6 alkylamino, mono- and di-(C 1 -C 4 alkyl)carboxamide, mono- and di(C 1 -C 4 alkyl)sulfonamide, and C 1 -C 4 alkylester, each of which is substituted with 0 or one or more substituents independently chosen from oxo, halogen, hydroxyl, cyano, nitro, —C(O)NH 2 , —C(O)OH, —S(O)NH 2 , C 1 -C 4 alkoxy, mono- and di-C 1 -C 6 alkylamino, mono- and di-(C 1 -C 4 alkyl)carboxamide, mono- or di(C 1 -C 4 alkyl)sulfonamide, C 1 -C 4 alkylester, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy
(e) (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, (heterocycloalkyl)C 0 -C 4 alkyl, and (phenyl)C 0 -C 4 alkyl, each of which is substituted with oxo, halogen, hydroxyl, cyano, amino, nitro, —C(O)NH 2 , —C(O)OH, —S(O)NH 2 , C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy;
R 3 is hydrogen;
R 4 is hydrogen, halogen, hydroxyl, amino, cyano, nitro, C 1 -C 2 alkyl, C 1 -C 2 alkoxy, C 1 -C 2 haloalkyl, C 1 -C 2 haloalkoxy or phenyl;
r is 0, 1, or 2.
17 . (canceled)
18 . The compound, salt, or hydrate of claim 16 , wherein R is halogen or trifluoromethyl, is 0 and R 4 is hydrogen, halogen, methyl, or phenyl.
19 . The compound, salt, or hydrate of claim 16 , wherein R 4 is fluorine.
20 . A pharmaceutical composition comprising one or more compounds, salts, or hydrates of claim 16 , together with at least one pharmaceutically acceptable excipient.
21 .- 24 . (canceled)
25 . A packaged pharmaceutical composition comprising the pharmaceutical composition of claim 20 , in a container, together with instructions for using the composition to treat a viral infection.
26 . The pharmaceutical composition of claim 20 , wherein the composition is formulated for oral administration.
27 . The compound, salt, or hydrate of claim 16 , wherein
r is 0 or 1; and Ar 1 is phenyl, naphthyl, a 5- or 6-membered heteroaryl group, or a 9- or 10-membered bicyclic heteroaryl group, wherein Ar 1 is substituted with R and R 1 , wherein when Ar 1 is phenyl or a 6-membered heteroaryl group there is an R 1 substituent in either the meta and para positions of the phenyl it substitutes; R is 0 or one or more substituents independently chosen from halogen, cyano, nitro, C 1 -C 2 alkyl, C 1 -C 2 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; R 1 is one substituent independently chosen from C 4 -C 10 alkyl, C 4 -C 10 alkenyl, C 4 -C 10 alkynyl, C 4 -C 10 alkanoyl, C 4 -C 10 alkylester, C 4 -C 10 alkoxy, mono- and di-C 4 -C 10 alkylcarboxamide, and a group —YZ, where Y is a bond, or Y is C 1 -C 10 alkyl, a C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, each optionally having 1 or 2 oxygen or nitrogen atoms within the alkyl, alkenyl, or alkynyl chain; and Z is C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkenyl, heterocycloalkyl, phenyl, naphthyl, indanyl, (C 3 -C 7 cycloalkyl)C 0 -C 10 alkoxy, or 5- to 6-membered heteroaryl containing 1, 2, 3, or 4 heteroatoms independently chosen from N, O, and S, wherein each group listed in the definition of R 1 is substituted with 0 or one or more substituents independently chosen from: halogen, hydroxyl, amino, cyano, nitro, oxo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy.
28 . The compound, salt, or hydrate of claim 16 wherein
Ar 1 is phenyl or pyridyl, each substituted with R and R 1 , wherein there is an R 1 substituent in either the meta and para positions of the group it substitutes; and r is 0.
29 . The compound, salt, or hydrate of claim 27 , wherein R is 0 substituents.
30 . The compound, salt or hydrate of claim 29 , wherein
R 1 is C 4 -C 10 alkyl, C 4 -C 10 alkenyl, C 4 -C 10 alkynyl, C 4 -C 10 alkanoyl, C 4 -C 10 alkylester, C 4 -C 10 alkoxy, mono- or di-C 4 -C 10 alkylcarboxamide, or a group —YZ, where Y is a bond, or Y is C 1 -C 10 alkyl, a C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, each optionally having 1 or 2 oxygen or nitrogen atoms within the alkyl, alkenyl, or alkynyl chain; and Z is C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkenyl, heterocycloalkyl, phenyl, naphthyl, indanyl, (C 3 -C 7 cycloalkyl)C 0 -C 10 alkoxy, or 5- to 6-membered heteroaryl containing 1, 2, 3, or 4 heteroatoms independently chosen from N, O, and S, wherein each group listed in the definition of R 1 is substituted with 0 or one or more substituents independently chosen from: halogen, hydroxyl, amino, cyano, nitro, oxo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy.
31 . The compound, salt, or hydrate of claim 30 , wherein
Ar 1 is phenyl or a 6-membered heteroaryl group substituted with an R 1 substituent in either the meta and para positions; and R 1 is C 4 -C 10 alkyl, C 4 -C 10 alkenyl, C 4 -C 10 alkynyl, C 4 -C 10 alkanoyl, C 4 -C 10 alkylester, C 4 -C 10 alkoxy, mono- or di-C 4 -C 10 alkylcarboxamide, or a group —YZ, where Y is a bond, or Y is C 4 -C 10 alkyl, a C 4 -C 10 alkenyl, or C 4 -C 10 alkynyl, each optionally having 1 or 2 oxygen or nitrogen atoms within the alkyl, alkenyl, or alkynyl chain; and Z is C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkenyl, heterocycloalkyl, phenyl, naphthyl, indanyl, (C 3 -C 7 cycloalkyl)C 0 -C 10 alkoxy, or 5- to 6-membered heteroaryl containing 1, 2, 3, or 4 heteroatoms independently chosen from N, O, and S, wherein each group listed in the definition of R 1 is substituted with 0 or one or more substituents independently chosen from: halogen, hydroxyl, amino, cyano, nitro, oxo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy.
32 . The compound of claim 30 , wherein
Ar 1 is phenyl or a 6-membered heteroaryl group substituted with an R 1 substituent in either the meta or para position; and R 1 is a group —YZ, where Y is a bond, or Y is C 4 -C 10 alkyl, a C 4 -C 10 alkenyl, or C 4 -C 10 alkynyl, each optionally having 1 or 2 oxygen or nitrogen atoms within the alkyl, alkenyl, or alkynyl chain; and Z is C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkenyl, heterocycloalkyl, phenyl, naphthyl, indanyl, (C 3 -C 7 cycloalkyl)C 0 -C 10 alkoxy, or 5- to 6-membered heteroaryl containing 1, 2, 3, or 4 heteroatoms independently chosen from N, O, and S, wherein each group listed in the definition of R 1 is substituted with 0 or one or more substituents independently chosen from: halogen, hydroxyl, amino, cyano, nitro, oxo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy.
33 . The compound, salt, or hydrate of claim 16 , wherein the compound is a compound of the formula
34 . The compound, salt, or hydrate of claim 33 , wherein r is 0 or 1.
35 . The compound, salt, or hydrate of claim 34 , wherein
R 4 is hydrogen or halogen; and R 2 is phenyl, a 5- to 6-membered heteroaryl, phenyl fused to a 5- or 6-membered cycloalkyl or heterocycloalkyl ring, or a bicyclic 8- to 10-membered heteroaryl, each of which is substituted with 0 or one or more substituents independently chosen from (c), (d), and (e); (c) halogen, hydroxyl, oxo, cyano, amino, nitro, —C(O)NH 2 , —C(O)OH, —S(O)NH 2 , C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy, (d) C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 2 -C 4 alkenyl, mono- and di-C 1 -C 6 alkylamino, mono- and di-(C 1 -C 4 alkyl)carboxamide, mono- and di(C 1 -C 4 alkyl)sulfonamide, and C 1 -C 4 alkylester, each of which is substituted with 0 or one or more substituents independently chosen from halogen, hydroxyl, oxo, cyano, nitro, —C(O)NH 2 , —C(O)OH, —S(O)NH 2 , C 1 -C 4 alkoxy, mono- and di-C 1 -C 6 alkylamino, mono- and di-(C 1 -C 4 alkyl)carboxamide, mono- and di(C 1 -C 4 alkyl)sulfonamide, C 1 -C 4 alkylester, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy, (e) (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, (heterocycloalkyl)C 0 -C 4 alkyl, (phenyl)C 0 -C 4 alkyl, each of which is substituted with oxo, halogen, hydroxyl, cyano, amino, nitro, —C(O)NH 2 , —C(O)OH, —S(O)NH 2 , C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy.
36 . The compound, salt, or hydrate of claim 35 wherein,
R 2 is phenyl or pyridyl, each of which is substituted with 0 or 1 or 2 substituents independently chosen from (c), (d), and (e).
37 . The compound, salt, or hydrate of claim 35 wherein,
R 2 is a 5- to 6-membered heteroaryl, phenyl fused to a 5 or 6 membered cycloalkyl or heterocycloalkyl ring, or a bicyclic 8- to 10-membered heteroaryl chosen from imidazo[2,1-b]thiazol-5-yl, pyrazinyl, 1H-imidazo[1,2-a]pyridin-3-yl, thiazolo[3,2-b][1,2,4]triazol-5-yl, isoxazol-3-yl, imidazo[1,2-a]pyridin-2-yl, thiazolyl, 2H-benzo[b][1,4]oxazin-3(4H)-one, benzo[d]thiazol-2-yl, thienyl, benzofuran-2-yl, benzo[d]oxazol-2(3H)-one, pyrimidinyl, imidazolyl, pyridizinyl, furanyl, benzo[d][1,3]dioxol-5-yl, naphthyl, quinolinyl, isobenzofuran-1(3H)-one, isobenzofuran-1(3H)-one, and 2H-benzo[b][1,4]thiazin-3(4H)-one, 1,2,3-thiadiazol-4-yl, each of which is substituted with 0 or 1 or more substituents independently chosen from halogen, oxo hydroxyl, amino, cyano, C 1 -C 4 alkyl, and C 1 -C 4 alkoxy.
38 . The compound, salt, or hydrate of claim 16 wherein, the compound is
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(4-fluorophenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
4-(4-(difluoromethoxy)phenyl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(4-fluorophenyl)-5-methylthiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-2-(pyridin-3-yl)thiazol-4-amine;
4-(4-fluorophenyl)-N-(4-pentylphenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(4-pentylphenyl)thiazol-2-amine;
4-(4-fluorophenyl)-N-(4-(pentyloxy)phenyl)thiazol-2-amine;
4-(3,4-dichlorophenyl)-N-(4-pentylphenyl)thiazol-2-amine;
4-(2,4-difluorophenyl)-N-(4-pentylphenyl)thiazol-2-amine;
4-(3,4-dichlorophenyl)-N-(4-(pentyloxy)phenyl)thiazol-2-amine;
4-(2,4-difluorophenyl)-N-(4-(pentyloxy)phenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(4-(pentyloxy)phenyl)thiazol-2-amine;
N-(3-(benzyloxy)phenyl)-4-(4-fluorophenyl)thiazol-2-amine;
N-(3-(benzyloxy)phenyl)-4-(3,4-dichlorophenyl)thiazol-2-amine;
N-(3-(benzyloxy)phenyl)-4-(2,4-difluorophenyl)thiazol-2-amine;
N-(3-(benzyloxy)phenyl)-4-(4-chlorophenyl)thiazol-2-amine;
4-(4-fluorophenyl)-N-(3-phenoxyphenyl)thiazol-2-amine;
4-(3,4-dichlorophenyl)-N-(3-phenoxyphenyl)thiazol-2-amine;
4-(2,4-difluorophenyl)-N-(3-phenoxyphenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(3-phenoxyphenyl)thiazol-2-amine;
N-(3-benzylphenyl)-4-(4-fluorophenyl)thiazol-2-amine;
N-(3-benzylphenyl)-4-(3,4-dichlorophenyl)thiazol-2-amine;
N-(3-benzylphenyl)-4-(2,4-difluorophenyl)thiazol-2-amine;
N-(3-benzylphenyl)-4-(4-chlorophenyl)thiazol-2-amine;
N-(4-benzylphenyl)-4-(4-fluorophenyl)thiazol-2-amine;
N-(4-benzylphenyl)-4-(3,4-dichlorophenyl)thiazol-2-amine;
N-(4-benzylphenyl)-4-(2,4-difluorophenyl)thiazol-2-amine;
N-(4-benzylphenyl)-4-(4-chlorophenyl)thiazol-2-amine;
N-(4-(4-fluorophenyl)thiazol-2-yl)-6-(pentyloxy)pyridin-3-amine;
N-(4-(3,4-dichlorophenyl)thiazol-2-yl)-6-(pentyloxy)pyridin-3-amine;
N-(4-(2,4-difluorophenyl)thiazol-2-yl)-6-(pentyloxy)pyridin-3-amine;
N-(4-(4-chlorophenyl)thiazol-2-yl)-6-(pentyloxy)pyridin-3-amine;
6-(pentyloxy)-N-(4-(pyridin-3-yl)thiazol-2-yl)pyridin-3-amine;
N-(3-fluoro-4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-((piperidin-1-yl)methyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(2,3-dihydro-1H-inden-2-yloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-fluorophenyl)-4-(pyridin-3-yl)thiazol-2-amine;
5-(4-(pyridin-3-yl)thiazol-2-ylamino)-2-(heptyloxy)benzonitrile;
N-(3-methyl-4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-butoxy-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-phenyl-benzyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-phenyl-benzyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-phenoxybenzyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-butoxybenzyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-butylbenzyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-phenoxyphenethyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-phenoxyphenethyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-pentylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(benzyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-phenoxyphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(phenethyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(hexyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-butoxyphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(heptyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(octyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-hexylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-octylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-butylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-benzylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-morpholinophenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-cyclohexylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(piperidin-1-yl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(1,2,3-thiadiazol-4-yl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(1H-imidazol-1-yl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(2-methylpyrimidin-4-yl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N1-isopropyl-N1-phenyl-N4-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,4-diamine;
butyl 4-(4-(pyridin-3-yl)thiazol-2-ylamino)benzoate;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-5-phenylthiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)-2-hydroxybenzamide;
4-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)benzonitrile;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(3,4-difluorophenyl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(4-methoxyphenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-5-phenylthiazol-2-amine;
2-(4-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)-5-methylthiazol-4-yl)phenoxy)acetic acid;
4-(4-chlorophenyl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-5-phenylthiazol-2-amine;
ethyl 2-(4-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)-5-methylthiazol-4-yl)phenoxy)acetate;
N-(4-phenoxyphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-chlorophenyl)thiazol-2-yl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-amine;
4,5-dihydro-1-phenyl-N-(4-(pyridin-3-yl)thiazol-2-yl)-1H-pyrazol-3-amine;
4-(4-fluorophenyl)-N-(4-phenoxyphenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(4-(4-fluorophenyl)thiazol-2-yl)thiazol-2-amine;
N-(4-(4-fluorophenyl)thiazol-2-yl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(6-methylpyridin-3-yl)thiazol-2-amine;
4-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)benzoic acid;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(pyrazin-2-yl)thiazol-2-amine;
N-(3-fluoro-4-(pentyloxy)phenyl)-4-(3-fluorophenyl)thiazol-2-amine;
4-(3-(3,4-dichlorophenyl)isoxazol-5-yl)-N-(3-fluoro-4-(pentyloxy)phenyl)thiazol-2-amine;
ethyl 5-(2-(3-fluoro-4-(pentyloxy)phenylamino)thiazol-4-yl)isoxazole-3-carboxylate;
4-(2-chlorophenyl)-N-(3-fluoro-4-(pentyloxy)phenyl)thiazol-2-amine;
N-(4-(3-fluorophenyl)thiazol-2-yl)-6-(pentyloxy)pyridin-3-amine;
N-(4-(3-(3,4-dichlorophenyl)isoxazol-5-yl)thiazol-2-yl)-6-(pentyloxy)pyridin-3-amine;
ethyl 5-(2-(6-(pentyloxy)pyridin-3-ylamino)thiazol-4-yl)isoxazole-3-carboxylate;
N-(4-(2-chlorophenyl)thiazol-2-yl)-6-(pentyloxy)pyridin-3-amine;
2-(4-(2-(4-pentylphenylamino)-5-methylthiazol-4-yl)phenyl)acetic acid;
4-(3-fluorophenyl)-N-(4-pentylphenyl)thiazol-2-amine;
4-(3-(3,4-dichlorophenyl)isoxazol-5-yl)-N-(4-pentylphenyl)thiazol-2-amine;
ethyl 5-(2-(4-pentylphenylamino)thiazol-4-yl)isoxazole-3-carboxylate;
4-(2-chlorophenyl)-N-(4-pentylphenyl)thiazol-2-amine;
2-(4-(2-(3-phenoxyphenylamino)-5-methylthiazol-4-yl)phenyl)acetic acid;
4-(3-fluorophenyl)-N-(3-phenoxyphenyl)thiazol-2-amine;
4-(3-(3,4-dichlorophenyl)isoxazol-5-yl)-N-(3-phenoxyphenyl)thiazol-2-amine;
ethyl 5-(2-(3-phenoxyphenylamino)thiazol-4-yl)isoxazole-3-carboxylate;
4-(2-chlorophenyl)-N-(3-phenoxyphenyl)thiazol-2-amine;
2-(4-(2-(3-(benzyloxy)phenylamino)-5-methylthiazol-4-yl)phenyl)acetic acid;
N-(3-(benzyloxy)phenyl)-4-(3-fluorophenyl)thiazol-2-amine;
N-(3-(benzyloxy)phenyl)-4-(3-(3,4-dichlorophenyl)isoxazol-5-yl)thiazol-2-amine;
ethyl 5-(2-(3-(benzyloxy)phenylamino)thiazol-4-yl)isoxazole-3-carboxylate;
N-(3-(benzyloxy)phenyl)-4-(2-chlorophenyl)thiazol-2-amine;
2-(4-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)-5-methylthiazol-4-yl)phenyl)acetic acid;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(3-fluorophenyl)thiazol-2-amine;
6-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one;
2-(5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
4-(3-(3,4-dichlorophenyl)isoxazol-5-yl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
ethyl 5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)isoxazole-3-carboxylate;
4-(2-chlorophenyl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
methyl 6-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)pyridine-3-carboxylate;
(5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)pyridin-2-yl)(morpholino)methanone;
6-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)pyridine-3-carboxylic acid;
6-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)-N,N-dimethylpyridine-3-carboxamide;
5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)-N,N-dimethylpyridine-2-carboxamide;
5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)-N-(carbamoylmethyl)-N-methylpyridine-2-carboxamide;
4-(5-(2-((4-(pentyloxy)-3-(trifluoromethyl)phenyl)amino)thiazol-4-yl)picolinoyl)piperazin-2-one;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(H-imidazo[1,2-a]pyridin-2-yl)thiazol-2-amine;
4-(3-methylimidazo[2,1-b]thiazol-5-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine;
4-(5,6-dihydroimidazo[2,1-b]thiazol-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine;
5-(2-(4-(pentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)-6H-1,3,4-thiadiazin-2-amine;
4-(4-((dimethylamino)methyl)phenyl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine;
N-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-isobutoxy-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(cyclopropylmethoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenyl)-4-(4-fluorophenyl)thiazol-2-amine;
4-(4-fluorophenyl)-N-(4-isobutoxy-3-(trifluoromethyl)phenyl)thiazol-2-amine;
N-(4-(cyclopropylmethoxy)-3-(trifluoromethyl)phenyl)-4-(4-fluorophenyl)thiazol-2-amine;
2-(5-(2-(4-isobutoxy-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
2-(4-(2-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenylamino)-5-methylthiazol-4-yl)phenyl)acetic acid;
2-(4-(2-(4-isobutoxy-3-(trifluoromethyl)phenylamino)-5-methylthiazol-4-yl)phenyl)acetic acid;
2-(5-(2-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
N-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenyl)-4-(4-methoxyphenyl)thiazol-2-amine;
N-(4-isobutoxy-3-(trifluoromethyl)phenyl)-4-(4-methoxyphenyl)thiazol-2-amine;
N-(4-(cyclopropylmethoxy)-3-(trifluoromethyl)phenyl)-4-(4-methoxyphenyl)thiazol-2-amine;
6-(2-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one;
6-(2-(4-isobutoxy-3-(trifluoromethyl)phenylamino)thiazol-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one;
6-(2-(4-(cyclopropylmethoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one;
5-(2-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)-2-hydroxybenzamide;
2-hydroxy-5-(2-(4-isobutoxy-3-(trifluoromethyl)phenylamino)thiazol-4-yl)benzamide;
5-(2-(4-(cyclopropylmethoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)-2-hydroxybenzamide;
N-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenyl)-4-(3,4-difluorophenyl)thiazol-2-amine;
2-(4-(2-(4-(cyclopropylmethoxy)-3-(trifluoromethyl)phenylamino)-5-methylthiazol-4-yl)phenyl)acetic acid;
N-methyl-5-(2-(4-(pentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)picolinamide;
4-(2-aminothiazol-4-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine;
4-(imidazo[1,2-a]pyrimidin-2-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine;
(5-(2-(4-(pentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)pyridin-2-yl)methanol;
N-(5-cyclohexyl-2-methoxyphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(2-methoxy-5-phenoxyphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
4-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)benzoic acid;
4-(2-aminothiazol-4-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(imidazo[1,2-a]pyrimidin-2-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(4-methoxyphenyl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
2-(4-(5-methyl-2-(4-(octyloxy)phenylamino)thiazol-4-yl)phenoxy)acetic acid;
4-(3,4-difluorophenyl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
N-(4-(octyloxy)phenyl)-4-phenylthiazol-2-amine;
4-(4-fluorophenyl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(3,4-dichlorophenyl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(2,4-difluorophenyl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)-1H-imidazol-2(5H)-one;
N-(4-(heptyloxy)phenyl)-4,5-diphenylthiazol-2-amine;
N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)-4-(thiophen-2-yl)thiazol-2-amine;
N-(4-(heptyloxy)phenyl)-4-(thiophen-2-yl)thiazol-2-amine;
N-(4-(octyloxy)phenyl)-4-(thiophen-2-yl)thiazol-2-amine;
4-(furo[3,2-c]pyridin-2-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine;
4-(furo[3,2-c]pyridin-2-yl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
4-(furo[3,2-c]pyridin-2-yl)-N-(3-phenoxyphenyl)thiazol-2-amine;
N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-4-yl)thiazol-2-amine;
N-(4-(heptyloxy)phenyl)-4-(pyridin-4-yl)thiazol-2-amine;
N-(3-phenoxyphenyl)-4-(pyridin-4-yl)thiazol-2-amine;
N-(4-(heptyloxy)phenyl)-4-(6-methylpyridin-3-yl)thiazol-2-amine;
4-(6-methylpyridin-3-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
2-(2-(4-(pentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)phenol;
2-(2-(4-(heptyloxy)phenylamino)thiazol-4-yl)phenol;
2-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)phenol;
4-(2-methoxyphenyl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine;
N-(4-(heptyloxy)phenyl)-4-(2-methoxyphenyl)thiazol-2-amine;
4-(2-methoxyphenyl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
5-(2-(4-(pentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)pyridin-2-ol;
4-(6-methoxypyridin-3-yl)-N-(4-(pentyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine;
4-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)benzene-1,2-diol;
4-(5-chlorothiophen-2-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(4-bromophenyl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
6-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)benzo[d]oxazol-2(3H)-one;
3-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)benzoic acid;
N-(4-(octyloxy)phenyl)-4-(pyridin-2-yl)thiazol-2-amine;
4-(1H-indol-3-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(benzo[d]thiazol-2-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(benzofuran-2-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(2-(4-(heptyloxy)phenylamino)thiazol-4-yl)benzene-1,2-diol;
4-(5-chlorothiophen-2-yl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
4-(4-bromophenyl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
6-(2-(4-(heptyloxy)phenylamino)thiazol-4-yl)benzo[d]oxazol-2(3H)-one;
3-(2-(4-(heptyloxy)phenylamino)thiazol-4-yl)benzoic acid;
N-(4-(heptyloxy)phenyl)-4-(pyridin-2-yl)thiazol-2-amine;
N-(4-(heptyloxy)phenyl)-4-(1H-indol-3-yl)thiazol-2-amine;
4-(benzo[d]thiazol-2-yl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
4-(benzofuran-2-yl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
4-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)benzene-1,2-diol;
4-(5-chlorothiophen-2-yl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
4-(4-bromophenyl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
6-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)benzo[d]oxazol-2(3H)-one;
3-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)benzoic acid;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(pyridin-2-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(1H-indol-3-yl)thiazol-2-amine;
4-(benzo[d]thiazol-2-yl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
4-(benzofuran-2-yl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
N-(4-(octyloxy)phenyl)-4-(pyridin-4-yl)thiazol-2-amine;
N-(3-fluoro-4-(pentyloxy)phenyl)-4-(pyridin-4-yl)thiazol-2-amine;
N-(3-fluoro-4-(pentyloxy)phenyl)-4-(pyridin-2-yl)thiazol-2-amine;
4-(benzofuran-2-yl)-N-(3-fluoro-4-(pentyloxy)phenyl)thiazol-2-amine;
4-(4-fluorophenyl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
4-(3,4-dichlorophenyl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
4-(2,4-difluorophenyl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
N-(4-(heptyloxy)phenyl)-4-(4-methoxyphenyl)thiazol-2-amine;
2-(4-(2-(4-(heptyloxy)phenylamino)-5-methylthiazol-4-yl)phenoxy)acetic acid;
4-(2-(3-fluoro-4-(pentyloxy)phenylamino)thiazol-4-yl)benzoic acid;
N-(3,5-difluoro-4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(2,5-dimethoxyphenyl)thiazol-2-amine;
N-(4-(heptyloxy)phenyl)-4-(2,5-dimethoxyphenyl)thiazol-2-amine;
N-(3-fluoro-4-(pentyloxy)phenyl)-4-(2,5-dimethoxyphenyl)thiazol-2-amine;
3-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)phenol;
3-(2-(4-(heptyloxy)phenylamino)thiazol-4-yl)phenol;
3-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)phenol;
N-(4-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)phenyl)acetamide;
N-(4-(2-(4-(heptyloxy)phenylamino)thiazol-4-yl)phenyl)acetamide;
N-(4-(2-(3-fluoro-4-(pentyloxy)phenylamino)thiazol-4-yl)phenyl)acetamide;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(2-methylpyridin-3-yl)thiazol-2-amine;
4-(2-methylpyridin-3-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(2,4,6-trimethylpyridin-3-yl)thiazol-2-amine;
N-(4-(heptyloxy)phenyl)-4-(2,4,6-trimethylpyridin-3-yl)thiazol-2-amine;
4-(2,4,6-trimethylpyridin-3-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
5-(2-(4-(heptyloxy)phenylamino)thiazol-4-yl)-2-hydroxybenzamide;
5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)-2-hydroxybenzamide;
4-(4-fluorophenyl)-N-(4-(hexyloxy)phenyl)thiazol-2-amine;
N-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenyl)-4-(6-methylpyridin-3-yl)thiazol-2-amine;
N-(4-(hexyloxy)phenyl)-4-(6-methylpyridin-3-yl)thiazol-2-amine;
5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)-N,N-dimethylpyridine-2-carboxamide;
5-(2-(4-(heptyloxy)phenylamino)thiazol-4-yl)-N,N-dimethylpyridine-2-carboxamide;
4-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)phenol;
4-(6-bromopyridin-3-yl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
4-(6-chloropyridin-3-yl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
ethyl 2-(4-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)phenoxy)acetate;
2-(4-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)phenoxy)acetic acid;
5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)-N-methylpyridin-2-amine;
5-(2-(6-(octyloxy)pyridin-3-ylamino)thiazol-4-yl)-N,N-dimethylpyridine-2-carboxamide;
6-(octyloxy)-N-(4-(pyridin-3-yl)thiazol-2-yl)pyridin-3-amine;
5-(2-(6-(octyloxy)pyridin-3-ylamino)thiazol-4-yl)-N,N-dimethylpyridine-2-carboxamide;
6-(octyloxy)-N-(4-(pyridin-3-yl)thiazol-2-yl)pyridin-3-amine;
N-(4-(6-methylpyridin-3-yl)thiazol-2-yl)-6-(octyloxy)pyridin-3-amine;
N-(4-(3,4-difluorophenyl)thiazol-2-yl)-6-(octyloxy)pyridin-3-amine;
N-(4-(4-fluorophenyl)thiazol-2-yl)-6-(octyloxy)pyridin-3-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-heptylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(6-fluoropyridin-3-yl)thiazol-2-amine;
4-(6-fluoropyridin-3-yl)-N-(4-(heptyloxy)phenyl)thiazol-2-amine;
4-(6-fluoropyridin-3-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(6-fluoropyridin-3-yl)-N-(4-octylphenyl)thiazol-2-amine;
N-(4-(3-cyclopentylpropoxy)-3-(trifluoromethyl)phenyl)-4-(4-fluorophenyl)thiazol-2-amine;
N-(4-(3-cyclopentylpropoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-cyclopentylpropoxy)-3-(trifluoromethyl)phenyl)-4-(6-methylpyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(pyrimidin-5-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-fluorophenyl)-4-(pyrimidin-5-yl)thiazol-2-amine;
N-(4-(octyloxy)phenyl)-4-(pyrimidin-5-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-fluorophenyl)-4-(6-methylpyridin-3-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-fluorophenyl)-4-(4-fluorophenyl)thiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)pyridine-2-carbonitrile;
5-(2-(4-(cyclohexylmethoxy)-3-fluorophenylamino)thiazol-4-yl)pyridine-2-carbonitrile;
5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-2-carbonitrile;
5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)pyridine-3-carbonitrile;
5-(2-(4-(heptyloxy)phenylamino)thiazol-4-yl)-N-methylpyridin-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(6-fluoropyridin-3-yl)thiazol-2-amine;
N-(3-fluoro-4-(pentyloxy)phenyl)-4-(6-fluoropyridin-3-yl)thiazol-2-amine;
N-(4-(3-cyclopentylpropoxy)-3-(trifluoromethyl)phenyl)-4-(6-fluoropyridin-3-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-fluorophenyl)-4-(6-fluoropyridin-3-yl)thiazol-2-amine;
4-(benzo[d][1,3]dioxol-6-yl)-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)thiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)-N-methylpyridin-2-amine;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-N-methylpyridin-2-amine;
5-(2-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)-N-methylpyridin-2-amine;
N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(quinolin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(quinolin-3-yl)thiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-N,N-dimethylpyridin-2-amine;
3-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)-1,8-naphthyridin-2-ol;
4-(4-fluorophenyl)-N-(4-octylphenyl)thiazol-2-amine;
5-(2-(4-octylphenylamino)thiazol-4-yl)-2-hydroxybenzamide;
4-(5-chlorothiophen-2-yl)-N-(4-octylphenyl)thiazol-2-amine;
4-(2-(4-octylphenylamino)thiazol-4-yl)benzene-1,2-diol;
6-(2-(4-octylphenylamino)thiazol-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one;
6-(2-(4-octylphenylamino)thiazol-4-yl)benzo[d]oxazol-2(3H)-one;
2-(4-(2-(4-octylphenylamino)-5-methylthiazol-4-yl)phenoxy)acetic acid;
N-(4-octylphenyl)-4-(pyridin-2-yl)thiazol-2-amine;
4-(benzofuran-2-yl)-N-(4-octylphenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(4-octylphenyl)thiazol-2-amine;
4-(4-fluorophenyl)-N-(4-heptylphenyl)thiazol-2-amine;
5-(2-(4-heptylphenylamino)thiazol-4-yl)-2-hydroxybenzamide;
4-(5-chlorothiophen-2-yl)-N-(4-heptylphenyl)thiazol-2-amine;
4-(2-(4-heptylphenylamino)thiazol-4-yl)benzene-1,2-diol;
6-(2-(4-heptylphenylamino)thiazol-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one;
6-(2-(4-heptylphenylamino)thiazol-4-yl)benzo[d]oxazol-2(3H)-one;
2-(4-(2-(4-heptylphenylamino)-5-methylthiazol-4-yl)phenoxy)acetic acid;
N-(4-heptylphenyl)-4-(pyridin-2-yl)thiazol-2-amine;
4-(benzofuran-2-yl)-N-(4-heptylphenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(4-heptylphenyl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(4-fluorophenyl)thiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-2-hydroxybenzamide;
4-(5-chlorothiophen-2-yl)-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)thiazol-2-amine;
4-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)benzene-1,2-diol;
6-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one;
6-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)benzo[d]oxazol-2(3H)-one;
2-(4-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)-5-methylthiazol-4-yl)phenoxy)acetic acid;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(pyridin-2-yl)thiazol-2-amine;
4-(benzofuran-2-yl)-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)thiazol-2-amine;
4-(4-chlorophenyl)-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(pyrazin-2-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(heptan-4-yloxy)phenyl)-4-(pyrazin-2-yl)thiazol-2-amine;
N-(4-(octyloxy)phenyl)-4-(pyrazin-2-yl)thiazol-2-amine;
ethyl 5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)pyridine-3-carboxylate;
ethyl 5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-3-carboxylate;
N-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenyl)-4-(pyrazin-2-yl)thiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-2-carbonitrile;
5-(2-(4-(3-cyclopentylpropoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)pyridine-2-carbonitrile;
5-(2-(3-fluoro-4-(pentyloxy)phenylamino)thiazol-4-yl)pyridine-2-carbonitrile;
5-(2-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)pyridine-2-carbonitrile;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(pyrimidin-5-yl)thiazol-2-amine;
N-(3-fluoro-4-(pentyloxy)phenyl)-4-(pyrimidin-5-yl)thiazol-2-amine;
4-(2-chloropyrimidin-5-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
4-(2-chloropyrimidin-5-yl)-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)thiazol-2-amine;
N-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenyl)-4-(pyrimidin-5-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(pentan-3-yloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)pyridine-3-carboxylic acid;
5-(2-(3-(trifluoromethyl)-4-(pentyloxy)phenylamino)thiazol-4-yl)-N,N-dimethylpyridine-3-carboxamide;
5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-3-carboxylic acid;
5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)-N,N-dimethylpyridine-3-carboxamide;
5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-3-carboxamide;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-3-carbonitrile;
5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-3-carbonitrile;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(5-methoxypyridin-3-yl)thiazol-2-amine;
4-(5-methoxypyridin-3-yl)-N-(4-(octyloxy)phenyl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-4-methylpyridin-2-ol;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)isobenzofuran-1(3H)-one;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(1-methyl-1H-imidazol-5-yl)thiazol-2-amine;
4-(benzo[c][1,2,5]thiadiazol-4-yl)-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)thiazol-2-amine;
6-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-1H-benzo[d][1,3]oxazine-2,4-dione;
2-(4-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)phenyl)ethanol;
3-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)thiophene-2-carboxamide;
7-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-2H-benzo[b][1,4]thiazin-3(4H)-one;
6-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridazin-3-amine;
3-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)thiophene-2-carbonitrile;
methyl 5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-2-chloropyridine-3-carboxylate;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(H-imidazo[1,2-a]pyridin-6-yl)thiazol-2-amine;
3-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)H-imidazo[1,2-a]pyridine-6-carbonitrile;
N-(3-(trifluoromethyl)-4-(octan-2-yloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(5-(2-(3-(trifluoromethyl)-4-(octan-2-yloxy)phenylamino)thiazol-4-yl)pyridin-2-yl)acetamide;
5-(2-(3-(trifluoromethyl)-4-(octan-2-yloxy)phenylamino)thiazol-4-yl)pyridin-2-amine;
N-(5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridin-2-yl)acetamide;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridin-2-amine;
N-(3-(trifluoromethyl)-4-(heptan-4-yloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(pyrimidin-2-yl)thiazol-2-amine;
N-(4-(3-phenylpropoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(octyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)pyridin-2-amine;
N-(5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-3-methylpyridin-2-yl)acetamide;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-3-methylpyridin-2-amine;
N-(5-(2-(4-(octyloxy)phenylamino)thiazol-4-yl)-3-methylpyridin-2-yl)acetamide;
N-(4-(3,7-dimethyloctyloxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-morpholinopropoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-(4-methylpiperazin-1-yl)propoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-(pyrrolidin-1-yl)propoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
octyl 4-(4-(pyridin-3-yl)thiazol-2-ylamino)-2-(trifluoromethyl)benzoate;
N-(3-(trifluoromethyl)-4-(octahydroisoquinolin-2(1H)-yl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
(4-(4-(4-fluorophenyl)thiazol-2-ylamino)-2-(trifluoromethyl)phenyl)(octahydroisoquinolin-2(1H)-yl)methanone;
octyl 4-(4-(4-fluorophenyl)thiazol-2-ylamino)-2-(trifluoromethyl)benzoate;
4-(6-deuterated-1,5-naphthyridin-2-yl)-N-(4-(octyloxy)-3-(trifluoromethyl)phenyl)thiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)furan-2-carbonitrile;
(5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)benzofuran-2-yl)methanol;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(6-methoxypyridin-2-yl)thiazol-2-amine;
4-(benzo[d][1,3]dioxol-5-yl)-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(quinolin-8-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(5-(trifluoromethyl)pyridin-2-yl)thiazol-2-amine;
2-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridin-3-ol;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(2,4-dimethoxypyrimidin-5-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(thiophen-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-amine;
2-heptyl-N-(4-(pyridin-3-yl)thiazol-2-yl)benzo[d]oxazol-5-amine;
2-heptyl-N-(4-(2-methoxypyrimidin-5-yl)thiazol-2-yl)benzo[d]oxazol-5-amine;
5-(2-(4-(cyclohexylmethoxy)-3-fluorophenylamino)thiazol-4-yl)isobenzofuran-1(3H)-one;
N-(4-(cyclohexylmethoxy)-3-fluorophenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-fluorophenyl)-4-(1-methyl-1H-imidazol-5-yl)thiazol-2-amine;
4-(benzo[c][1,2,5]thiadiazol-4-yl)-N-(4-(cyclohexylmethoxy)-3-fluorophenyl)thiazol-2-amine;
6-(2-(4-(cyclohexylmethoxy)-3-fluorophenylamino)thiazol-4-yl)-1H-benzo[d][1,3]oxazine-2,4-dione;
2-(4-(2-(4-(cyclohexylmethoxy)-3-fluorophenylamino)thiazol-4-yl)phenyl)ethanol;
3-(2-(4-(cyclohexylmethoxy)-3-fluorophenylamino)thiazol-4-yl)thiophene-2-carboxamide;
7-(2-(4-(cyclohexylmethoxy)-3-fluorophenylamino)thiazol-4-yl)-2H-benzo[b][1,4]thiazin-3(4H)-one;
5-(2-(4-(cyclohexylmethoxy)-3-fluorophenylamino)thiazol-4-yl)pyridine-3-carbonitrile;
3-(2-(4-(cyclohexylmethoxy)-3-fluorophenylamino)thiazol-4-yl)thiophene-2-carbonitrile;
ethyl 6-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-2-carboxylate;
ethyl 2-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)thiazole-4-carboxylate;
ethyl 2-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)thiazole-5-carboxylate;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridin-2-ol;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(6-methoxypyridin-3-yl)thiazol-2-amine;
5-(2-(4-(cyclopentyloxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)-N,N-dimethylpyridin-2-amine;
2-phenyl-N-(4-(pyridin-3-yl)thiazol-2-yl)benzo[d]oxazol-5-amine;
3-(4-chlorophenyl)-N-(4-(pyridin-3-yl)thiazol-2-yl)-1H-pyrazol-5-amine;
N-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-chloro-4-morpholinophenyl)-4-(pyridin-3-yl)thiazol-2-amine;
1,2,3,4-tetrahydro-2-methyl-4-phenyl-N-(4-(pyridin-3-yl)thiazol-2-yl)isoquinolin-8-amine;
N-(4-(pyridin-3-yl)thiazol-2-yl)-3-(thiophen-2-yl)-1H-pyrazol-5-amine;
1-methyl-3-phenyl-N-(4-(pyridin-3-yl)thiazol-2-yl)-1H-pyrazol-5-amine;
N-(3-(oxazol-4-yl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
2-(4-fluorophenyl)-N-(4-(pyridin-3-yl)thiazol-2-yl)-2H-benzo[d][1,2,3]triazol-5-amine;
6-phenoxy-N-(4-(pyridin-3-yl)thiazol-2-yl)pyridin-3-amine;
3-phenyl-N-(4-(pyridin-3-yl)thiazol-2-yl)-1H-pyrazol-5-amine;
6-phenyl-N-(4-(pyridin-3-yl)thiazol-2-yl)pyridin-3-amine;
N-(4-phenethylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)(phenyl)methanone;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-4-(2-deuterated-1,5-naphthyridin-6-yl)thiazol-2-amine;
5-(2-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)furan-2-carbonitrile;
(5-(2-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)benzofuran-2-yl)methanol;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-4-(5-(trifluoromethyl)pyridin-2-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-4-(2,4-dimethoxypyrimidin-5-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-4-(4-methylpyridin-2-yl)thiazol-2-amine;
ethyl 2-(2-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiazole-4-carboxylate;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(1-methyl-1H-benzo[d]imidazol-2-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-4-(3-(trifluoromethyl)phenyl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-4-(6-methoxypyridin-2-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-4-(2-methoxynaphthalen-6-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-4-(quinolin-8-yl)thiazol-2-amine;
N-(4-(3,7-dimethyloctyloxy)-3-(trifluoromethyl)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
(4-(4-(2-methoxypyrimidin-5-yl)thiazol-2-ylamino)-2-(trifluoromethyl)phenyl)(octahydroisoquinolin-2(1H)-yl)methanone;
octyl 4-(4-(2-methoxypyrimidin-5-yl)thiazol-2-ylamino)-2-(trifluoromethyl)benzoate;
N-(3-(trifluoromethyl)-4-(oct-1-ynyl)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octahydroisoquinolin-2(1H)-yl)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
4-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)benzene-1,3-diol;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(1-methyl-1H-pyrrol-2-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-5-nitro-4-(pyridin-3-yl)thiazol-2-amine;
N-(5-(trifluoromethyl)-2-nitro-4-(octyloxy)phenyl)-5-nitro-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(oct-1-ynyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
3-(4-(trifluoromethyl)phenyl)-N-(4-(pyridin-3-yl)thiazol-2-yl)isoxazol-5-amine;
butyl 5-(4-(pyridin-3-yl)thiazol-2-ylamino)-1H-1,2,4-triazole-3-carboxylate;
3-phenyl-N-(4-(pyridin-3-yl)thiazol-2-yl)-1,2,4-thiadiazol-5-amine;
4-tert-butyl-N-(4-(pyridin-3-yl)thiazol-2-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(imidazo[2,1-b]thiazol-6-yl)thiazol-2-amine;
N-(4-(4-(thiophen-2-yl)butoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-(pyridin-3-yl)propoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
3-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)imidazo[2,1-b]thiazol-6(5H)-one;
N-(4-(3-cyclopentylpropoxy)-3-(trifluoromethyl)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(4-(4-phenylbutoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-p-tolylbutoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-(pyridin-3-yl)propoxy)-3-(trifluoromethyl)phenyl)-4-(4-fluorophenyl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(imidazo[2,1-b]thiazol-3-yl)thiazol-2-amine;
4-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-1H-pyrazole-3-carbonitrile;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyrimidin-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(1H-imidazol-5-yl)thiazol-2-amine;
4-(2-chlorothiophen-3-yl)-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)thiazol-2-amine;
3-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-2-carbonitrile;
3-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridine-2-carboxamide;
4-(naphthalen-2-yl)-N-(4-(pyridin-3-yl)thiazol-2-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(oct-1-enyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(heptyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-methylpentyloxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-octylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-octylphenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(4-(4-phenylbutoxy)-3-(trifluoromethyl)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(4-(4-p-tolylbutoxy)-3-(trifluoromethyl)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(4-(3-(pyridin-3-yl)propoxy)-3-(trifluoromethyl)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(4-(3-phenylpropoxy)-3-(trifluoromethyl)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
4-((piperidin-1-yl)methyl)-N-(4-(pyridin-3-yl)thiazol-2-yl)thiazol-2-amine;
6-butyl-N-(4-(pyridin-3-yl)thiazol-2-yl)benzo[d]thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-5-methyl-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-cyclopentylpropoxy)-3-(trifluoromethyl)phenyl)-5-methyl-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-phenylbutoxy)-3-(trifluoromethyl)phenyl)-5-methyl-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-phenylpropoxy)-3-(trifluoromethyl)phenyl)-5-methyl-4-(pyridin-3-yl)thiazol-2-amine;
5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyrimidin-2-ol;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(6-methoxypyridazin-3-yl)thiazol-2-amine;
4-(6-chloro-5-methylpyridin-3-yl)-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)thiazol-2-amine;
tert-butyl (5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)pyridin-2-yl)methylcarbamate;
N-(4-(4-p-tolylbutoxy)-3-(trifluoromethyl)phenyl)-5-methyl-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-(pyridin-3-yl)propoxy)-3-(trifluoromethyl)phenyl)-5-methyl-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(2-phenoxyethoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
2-(5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
2-(5-(2-(4-(3-cyclopentylpropoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
2-(5-(2-(4-(4-p-tolylbutoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
N-(4-(4-(thiophen-2-yl)butoxy)-3-fluorophenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-phenylpropoxy)-3-fluorophenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-(thiophen-2-yl)butoxy)-3-fluorophenyl)-5-methyl-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-phenylpropoxy)-3-fluorophenyl)-5-methyl-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(cyclohexylmethoxy)-3-(trifluoromethyl)phenyl)-5-methyl-4-(pyridin-3-yl)thiazol-2-amine;
N 2 -(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(4-fluorophenyl)thiazole-2,5-diamine;
N 2 -(4-(benzyloxy)phenyl)-4-(4-fluorophenyl)thiazole-2,5-diamine;
N-(4-(3-(furan-2-yl)propoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(3-(furan-2-yl)propoxy)-3-fluorophenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(5-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)-1H-imidazol-2-yl)acetamide;
1-(4-fluorobenzyl)-N-(4-(2-methoxypyrimidin-5-yl)thiazol-2-yl)-1H-indol-6-amine;
1-(4-fluorobenzyl)-N-(4-(pyridin-3-yl)thiazol-2-yl)-1H-indol-6-amine;
1-(4-fluorobenzyl)-N-(4-(4-fluorophenyl)thiazol-2-yl)-1H-indol-6-amine;
1-(4-fluorobenzyl)-N-(4-(pyridin-3-yl)thiazol-2-yl)-1H-indol-5-amine;
1-(4-fluorobenzyl)-N-(4-(4-fluorophenyl)thiazol-2-yl)-1H-indol-5-amine;
N-(4-sec-butylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-tert-butylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-tert-butylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-chlorophenoxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(p-tolyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
3-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-1-(2,3,4,5,6-pentamethylphenyl)propan-1-one;
N-(4-butyl-2-methylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-phenylbutoxy)-3-fluorophenyl)-4-(pyridin-3-yl)thiazol-2-amine;
2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)-4-(pyridin-3-yl)thiazole-5-carbonitrile;
5-fluoro-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(2-methylthiazol-4-yl)thiazol-2-amine;
4-(2-(3-(trifluoromethyl)-4-(octyloxy)phenylamino)thiazol-4-yl)thiazol-2-amine;
5-chloro-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
1-(4-fluorobenzyl)-N-(4-(2-methoxypyrimidin-5-yl)thiazol-2-yl)-1H-indol-5-amine;
N-(4-(3-phenylpropoxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-phenylbutoxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-(thiophen-2-yl)butoxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N 2 -(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(pyridin-3-yl)thiazole-2,5-diamine;
N-(4-(3-phenoxypropoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
2-(5-(2-(4-(4-(thiophen-2-yl)butoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
ethyl-2-(5-(2-(4-(4-(thiophen-2-yl)butoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetate;
2-(5-(2-(4-(4-phenylbutoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
ethyl 2-(5-(2-(4-(4-phenylbutoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetate;
2-(5-(2-(4-(4-phenylbutoxy)-3-fluorophenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
ethyl 2-(5-(2-(4-(4-phenylbutoxy)-3-fluorophenylamino)thiazol-4-yl)thiophen-2-yl)acetate;
ethyl 2-(5-(2-(4-(3-phenoxypropoxy)phenylamino)thiazol-4-yl)thiophen-2-yl)acetate;
ethyl 2-(5-(2-(4-(2-phenoxyethoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetate;
N-(4-(4-m-tolylbutoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-phenylbutoxy)-3-methylphenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(5-phenylpentyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(3-(trifluoromethyl)-4-(5-phenylpentyl)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(4-(4-phenylbutoxy)-3-(trifluoromethyl)phenyl)-4-(pyrazin-2-yl)thiazol-2-amine;
N-(4-(4-(thiophen-2-yl)butoxy)-3-(trifluoromethyl)phenyl)-4-(pyrazin-2-yl)thiazol-2-amine;
N-(4-(4-phenylbutoxy)-3-fluorophenyl)-4-(pyrazin-2-yl)thiazol-2-amine;
2-(5-(2-(4-(3-(furan-2-yl)propoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetic acid;
ethyl-2-(5-(2-(4-(3-(furan-2-yl)propoxy)-3-(trifluoromethyl)phenylamino)thiazol-4-yl)thiophen-2-yl)acetate;
N-(4-(3-cyclopentylpropoxy)-3-(trifluoromethyl)phenyl)-5-fluoro-4-(pyridin-3-yl)thiazol-2-amine;
5-fluoro-N-(3-(trifluoromethyl)-4-(octyloxy)phenyl)-4-(2-methoxypyrimidin-5-yl)thiazol-2-amine;
N-(4-(4-(4-fluorophenyl)butoxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-p-tolylbut-3-ynyloxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine;
N-(4-(4-m-tolylbut-3-ynyloxy)-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine; and
5-fluoro-N-(3-(trifluoromethyl)-4-(pentyloxy)phenyl)-4-(pyridin-3-yl)thiazol-2-amine.Join the waitlist — get patent alerts
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