Adhesive-based varicose vein treatment

Abstract

An intraluminal member can be used to deliver an adhesive to a vein while causing the vein to spasm, thereby controlling adhesive migration and improving procedure efficacy.

1 . A method of permanently occluding a vein through the combined spasm of the vein and injection of an adhesive, comprising the following steps:
 advancing an elongated intraluminal member from an access site and into the vein, wherein the intraluminal member comprises a perturbing portion configured to perturb an inner vessel wall of the vein under user control when performing a defined movement;   perturbing the inner vessel wall by performing the defined movement of the perturbing portion of the intraluminal member, thereby inducing a region of the vein to spasm and reduce its diameter; and   injecting sufficient adhesive at or near the reduced-diameter region of the vein to occlude the vein permanently.   
     
     
         2 . The method of  claim 1 , wherein the adhesive is injected in such as manner as to occlude the vein at a location distal to the region of spasm. 
     
     
         3 . The method of  claim 1 , wherein the adhesive is injected in such as manner as to occlude the vein at a location proximal to the area of spasm. 
     
     
         4 . The method of  claim 1 , wherein the perturbing portion is a tip of a wire and the defined movement includes rotating the tip so that the tip contacts the inner vessel wall. 
     
     
         5 . The method of  claim 4 , wherein the defined movement further comprises moving the tip of the wire longitudinally along the vein. 
     
     
         6 . The method of  claim 5 , wherein the tip of the wire is simultaneously rotated and moved longitudinally. 
     
     
         7 . The method of  claim 4 , wherein the wire tip has a blade configuration that generates backflow of blood in the vessel when the wire is rotated. 
     
     
         8 . The method of  claim 1 , further comprising injecting sclerosant at or near the reduced- diameter region of the vein. 
     
     
         9 . The method of  claim 8 , wherein the sclerosant and the adhesive are injected simultaneously. 
     
     
         10 . The method of  claim 8 , wherein the sclerosant is injected first, and the adhesive is injected after the sclerosant. 
     
     
         11 . The method of  claim 8 , wherein the adhesive is injected first, and the sclerosant is injected after the adhesive. 
     
     
         12 . The method of  claim 1 , further comprising observing the treatment site and waiting to inject the adhesive until a reduction in the vein diameter is observed. 
     
     
         13 . The method of  claim 12 , wherein observing comprises ultrasound imaging. 
     
     
         14 . The method of  claim 1 , further comprising exposing the adhesive to UV light so as to cure the adhesive. 
     
     
         15 . The method of  claim 1 , further comprising applying external compression on the catheter tip before, during, or after injection of sclerosant. 
     
     
         16 . The method of  claim 15 , wherein the external compression is applied with an ultrasound probe. 
     
     
         17 . Method of  claim 15 , wherein the spasm is accentuated by external compression on the catheter tip at the injection site with the palm of the operator. 
     
     
         18 . The method of  claim 15 , wherein the adhesive is injected in such as manner as to occlude the vein at a location distal to the region of spasm. 
     
     
         19 . The method of  claim 15 , wherein the adhesive is injected in such as manner as to occlude the vein at a location proximal to the area of spasm. 
     
     
         20 . The method of  claim 15 , wherein the perturbing portion is a tip of a wire and the defined movement includes rotating the tip so that the tip contacts the inner vessel wall. 
     
     
         21 . The method of  claim 20 , wherein the defined movement further comprises moving the tip of the wire longitudinally along the vein. 
     
     
         22 . The method of  claim 21 , wherein the tip of the wire is simultaneously rotated and moved longitudinally. 
     
     
         23 . The method of  claim 20 , wherein the wire tip has a blade configuration that generates backflow of blood in the vessel when the wire is rotated. 
     
     
         24 . The method of  claim 15 , further comprising injecting sclerosant at or near the reduced-diameter region of the vein. 
     
     
         25 . The method of  claim 24 , wherein the sclerosant and the adhesive are injected simultaneously. 
     
     
         26 . The method of  claim 24 , wherein the sclerosant is injected first, and the adhesive is injected after the sclerosant. 
     
     
         27 . The method of  claim 24 , wherein the adhesive is injected first, and the sclerosant is injected after the adhesive. 
     
     
         28 . The method of  claim 1 , further comprising observing the treatment site and waiting to inject the adhesive until a reduction in the vein diameter is observed. 
     
     
         29 . The method of  claim 28 , wherein observing comprises ultrasound imaging. 
     
     
         30 . The method of  claim 15 , further comprising exposing the adhesive to UV light so as to cure the adhesive.