Treatment of holocrine gland dysfunction with clostridia neurotoxins

Abstract

Methods of using clostridial toxins and other biological agents to control holocrine gland dysfunction in humans is provided. In preferred embodiments the methods provide beneficial effects in humans.

1 - 12 . (canceled) 
     
     
         13 - 28 . (canceled) 
     
     
         29 . A method of treating unwanted lactation or mammalian hypertrophy in a subject in need of such treatment which comprises administering to a breast of said subject a therapeutically effective amount of Botulinum toxin. 
     
     
         30 . The method of  claim 29 , wherein the administration is topical. 
     
     
         31 . The method of  claim 29 , wherein the Botulinum toxin is Botulinum toxin A. 
     
     
         32 . The method of  claim 29 , wherein the administration is by injection into the breast. 
     
     
         33 . The method of  claim 32 , comprising injection at multiple sites, wherein the sites of adjacent injections are separated by about 0.5 to 10 cm. 
     
     
         34 . The method of  claim 33 , wherein the sites of adjacent injections are separated by about 1.5 to about 3 cm. 
     
     
         35 . The method of  claim 29 , wherein the amount administered is between 0.1 and 1000 U of Botulinum toxin. 
     
     
         36 . The method of  claim 29 , wherein the amount administered is between 1 and 100 U of Botulinum toxin. 
     
     
         37 . The method of  claim 29 , wherein the amount administered is between 2 and 3 U of Botulinum toxin. 
     
     
         38 . The method of  claim 29 , wherein said method is repeated at intervals of from about 3 to about 6 months to inhibit said recurrence. 
     
     
         39 . The method of  claim 29 , wherein said method is repeated at intervals of about 4 months to inhibit said recurrence. 
     
     
         40 . The method of  claim 29 , wherein the Botulinum toxin is chosen from the group consisting of Botulinum toxin B, Botulinum toxin C, Botulinum toxin D, Botulinum toxin E, Botulinum toxin F and Botulinum toxin G.