Ethanamine Compounds and Methods of Using the Same

Abstract

The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound.

1 - 48 . (canceled) 
     
     
         49 . A compound selected from the group consisting of:
 1-(3-fluorophenyl)-2-methyl-2-(pyridin-2-yl)propan-1-amine;   (R)-1-(3-fluorophenyl)-2-methyl-2-(pyridin-2-yl)propan-1-amine;   (S)-1-(3-fluorophenyl)-2-methyl-2-(pyridin-2-yl)propan-1-amine;   2-methyl-1-phenyl-2-(pyridin-2-yl)propan-1-amine, and   (S)-2-methyl-1-phenyl-2-(pyridin-2-yl)propan-1-amine,   
       or a pharmaceutically acceptable salt of any foregoing compound. 
     
     
         50 . A salt selected from the group consisting of:
 1-(3-fluorophenyl)-2-methyl-2-(pyridin-2-yl)propan-1-amine fumarate   (R)-1-(3-fluorophenyl)-2-methyl-2-(pyridin-2-yl)propan-1-amine fumarate;   (S)-1-(3-fluorophenyl)-2-methyl-2-(pyridin-2-yl)propan-1-amine fumarate;   2-methyl-1-phenyl-2-(pyridin-2-yl)propan-1-amine fumarate;   (R)-2-methyl-1-phenyl-2-(pyridin-2-yl)propan-1-amine fumarate, and   (S)-2-methyl-1-phenyl-2-(pyridin-2-yl)propan-1-amine fumarate.   
     
     
         51 . A method of treating depression or major depressive disorder in a human which comprises administering to a person in need thereof a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof according to  claim 49 . 
     
     
         52 . A method of treating depression or major depressive disorder in a human which comprises administering to a person in need thereof a therapeutically effective amount of a salt according to  claim 50 . 
     
     
         53 . A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof according to  claim 49  and a pharmaceutically acceptable adjuvant, carrier, or diluent. 
     
     
         54 . A pharmaceutical composition comprising a salt according to  claim 50  and a pharmaceutically acceptable adjuvant, carrier, or diluent.