Therapeutic Compositions And Methods

Abstract

The present invention relates in general to therapeutic compositions and methods of use. In preferred embodiments, the invention relates to the field of eye health. In some embodiments, the invention relates to the prevention and treatment of macular degeneration by administering compounds disclosed herein. In some embodiments, the invention relates to compositions and methods of improving vision. The present invention includes compositions and methods that provide protection in a patient suffering from an eye disease such as age-related macular degeneration. In certain embodiments, the compositions of the present invention are administered during degeneration, and the composition includes an effective amount of an agent that increases choroidal blood flow.

1 - 14 . (canceled) 
     
     
         15 . A method of treating macular degeneration comprising:
 1) providing
 i) a subject diagnosed with macular degeneration and 
 ii) a composition comprising guanabenz or salt thereof and 
   2) administering said compound to said subject.   
     
     
         16 . The method of  claim 15 , wherein said macular degeneration is age-related. 
     
     
         17 . The method of  claim 15 , wherein said subject is a human. 
     
     
         18 . The method above of  claim 15 , said administration is topically to the eye. 
     
     
         19 . The method above of  claim 15 , said salt is selected from the group of a hydrochloride salt and an acetate salt. 
     
     
         20 . The method of  claim 15 , wherein said composition is a liquid solution. 
     
     
         21 . A method of treating macular degeneration comprising:
 1) providing
 i) a subject diagnosed with macular degeneration and 
 ii) a composition comprising a substituted or unsubstituted compound of the following formula: 
   
       
         
           
           
               
               
           
         
         
            or salt thereof functioning to decrease choroidal neovascularization and 
         
         2) administering said compound to said subject.