3,5-disubstituted and 3,5,7-trisubstituted-3h-oxazolo and 3h-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof

Abstract

The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.

1 - 40 . (canceled) 
     
     
         41 . A method of treating a tumor or cancer in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or tautomer thereof. 
       
     
     
         42 . The method according to  claim 41 , wherein the tumor or cancer is caused by a virus. 
     
     
         43 . The method according to  claim 41 , wherein the tumor or cancer is selected from the group consisting of carcinomas, sarcomas, and leukemias. 
     
     
         44 . The method according to  claim 43 , wherein the carcinoma is a mammary, colon, bladder, lung, prostate, stomach, or pancreas carcinoma. 
     
     
         45 . The method according to  claim 43 , wherein the leukemia is a lymphoblastic or myeloid leukemia. 
     
     
         46 . The method according to  claim 41 , further comprising administering to said patient a therapeutically effective amount of a therapeutic agent selected from the group consisting of antibiotics, antiemetic agents, antidepressants, antifungal agents, anti-inflammatory agents, antiviral agents, anticancer agents, immunomodulatory agents, β-interferons, alkylating agents, hormones, and cytokines. 
     
     
         47 . A method of treating a tumor or cancer in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a compound that is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         48 . The method according to  claim 47 , wherein the tumor or cancer is caused by a virus. 
     
     
         49 . The method according to  claim 47 , wherein the tumor or cancer is selected from the group consisting of carcinomas, sarcomas, and leukemias. 
     
     
         50 . The method according to  claim 49 , wherein the carcinoma is a mammary, colon, bladder, lung, prostate, stomach, or pancreas carcinoma. 
     
     
         51 . The method according to  claim 49 , wherein the leukemia is a lymphoblastic or myeloid leukemia. 
     
     
         52 . The method according to  claim 47 , further comprising administering to said patient a therapeutically effective amount of a therapeutic agent selected from the group consisting of antibiotics, antiemetic agents, antidepressants, antifungal agents, anti-inflammatory agents, antiviral agents, anticancer agents, immunomodulatory agents, β-interferons, alkylating agents, hormones, and cytokines. 
     
     
         53 . The method according to  claim 47 , wherein the compound is orally administered to said patient. 
     
     
         54 . A method of treating a tumor or cancer in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a compound that is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or tautomer thereof. 
       
     
     
         55 . The method according to  claim 54 , wherein the tumor or cancer is caused by a virus. 
     
     
         56 . The method according to  claim 54 , wherein the tumor or cancer is selected from the group consisting of carcinomas, sarcomas, and leukemias. 
     
     
         57 . The method according to  claim 56 , wherein the carcinoma is a mammary, colon, bladder, lung, prostate, stomach, or pancreas carcinoma. 
     
     
         58 . The method according to  claim 56 , wherein the leukemia is a lymphoblastic or myeloid leukemia. 
     
     
         59 . The method according to  claim 54 , further comprising administering to said patient a therapeutically effective amount of a therapeutic agent selected from the group consisting of antibiotics, antiemetic agents, antidepressants, antifungal agents, anti-inflammatory agents, antiviral agents, anticancer agents, immunomodulatory agents, β-interferons, alkylating agents, hormones, and cytokines 
     
     
         60 . The method according to  claim 54 , wherein the compound is administered to said patient in an oral or parenteral dosage form.