US2012122178A1PendingUtilityA1

Human Aminoacyl-tRNA Synthetase Polypeptides Useful for the Regulation of Angiogenesis

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Assignee: SCHIMMEL PAULPriority: Mar 21, 2001Filed: Jan 23, 2012Published: May 17, 2012
Est. expiryMar 21, 2021(expired)· nominal 20-yr term from priority
Inventors:Paul SchimmelKeisuke Wakasugi
C12N 9/93A61K 38/00
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Claims

Abstract

The present invention provides an isolated polypeptide comprising residues 94-471 of SEQ ID NO: 10, wherein the isolated polypeptide does not comprise amino acid residues 1-47 of SEQ ID NO: 10. Nucleic acids and expression vectors encoding the peptide also are provided.

Claims

exact text as granted — not AI-modified
1 . An isolated polypeptide comprising residues 94-471 of SEQ ID NO: 10, wherein the isolated polypeptide does not comprise amino acid residues 1-47 of SEQ ID NO:10. 
     
     
         2 . The isolated polypeptide of  claim 1 , wherein the polypeptide consists of residues 48-471 of SEQ ID NO: 10. 
     
     
         3 . The isolated polypeptide of  claim 1 , wherein the polypeptide comprises residues 71-471 of SEQ ID NO: 10. 
     
     
         4 . The isolated polypeptide of  claim 1 , wherein the polypeptide comprises residues 48-471 of SEQ ID NO: 10. 
     
     
         5 . An isolated nucleic acid comprising a polynucleotide sequence that encodes a polypeptide, wherein the polypeptide comprises residues 94-471 of SEQ ID NO: 10, and wherein the polypeptide does not comprise amino acid residues 1-47 of SEQ ID NO:10. 
     
     
         6 . The isolated nucleic acid of  claim 5 , wherein the polypeptide consists of residues 94-471 of SEQ ID NO: 10. 
     
     
         7 . The isolated nucleic acid of  claim 5 , wherein the polypeptide consists of residues 71-471 of SEQ ID NO: 10. 
     
     
         8 . The isolated nucleic acid of  claim 5 , wherein the polypeptide consists of residues 48-471 of SEQ ID NO: 10. 
     
     
         9 . The isolated nucleic acid of  claim 5 , wherein the polypeptide comprises residues 71-471 of SEQ ID NO: 10. 
     
     
         10 . The isolated nucleic acid of  claim 5 , wherein the polypeptide comprises residues 48-471 of SEQ ID NO: 10. 
     
     
         11 . The isolated nucleic acid of  claim 5 , wherein the polynucleotide sequence encodes a polypeptide comprising residues 48-471 of SEQ ID NO: 10 and the region of the polynucleotide that encodes residues 48-471 of SEQ ID NO: 10 comprises residues 3569 to 4840 of SEQ ID NO: 9. 
     
     
         12 . The isolated nucleic acid of  claim 5 , wherein the polynucleotide sequence encodes a polypeptide comprising residues 71-471 of SEQ ID NO: 10 and the region of the polynucleotide that encodes residues 71-471 of SEQ ID NO: 10 comprises residues 3638 to 4840 of SEQ ID NO: 9. 
     
     
         13 . An expression vector comprising a polynucleotide sequence that encodes a polypeptide, wherein the polypeptide comprises residues 94-471 of SEQ ID NO: 10, and wherein the polypeptide does not comprise amino acid residues 1-47 of SEQ ID NO:10. 
     
     
         14 . The expression vector of  claim 13 , wherein the polypeptide consists of residues 94-471 of SEQ ID NO: 10. 
     
     
         15 . The expression vector of  claim 13 , wherein the polypeptide consists of residues 71-471 of SEQ ID NO: 10. 
     
     
         16 . The expression vector of  claim 13 , wherein the polypeptide consists of residues 48-471 of SEQ ID NO: 10. 
     
     
         17 . The expression vector of  claim 13 , wherein the polypeptide comprises residues 71-471 of SEQ ID NO: 10. 
     
     
         18 . The expression vector of  claim 13 , wherein the polypeptide comprises residues 48-471 of SEQ ID NO: 10.

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