Prophylactic, ameliorating or therapeutic agent for oral diseases

Abstract

To provide a novel lactic acid bacterium strain having a broad antibacterial spectrum against bacteria that cause oral diseases, from which a fermented product having good flavor and being excellent in palatability can be produced, and a prophylactic, ameliorating or therapeutic agent for oral diseases using the same. A prophylactic, ameliorating or therapeutic agent for an oral disease, which contains a lactic acid bacterial cell of one or more kinds selected from the group consisting of Lactobacillus rhamnosus strain KO3, Lactobacillus casei strain YU3 and Lactobacillus paracasei strain YU4 or a culture of the cell, or an extract thereof, as an active ingredient.

1 . A prophylactic, ameliorating or therapeutic agent for an oral disease, comprising:
 a lactic acid bacterial cell of one or more kinds selected from the group consisting of  Lactobacillus rhamnosus  strain KO3 (NITE BP-771),  Lactobacillus casei  strain YU3 (NITE BP-772) and  Lactobacillus paracasei  strain YU4 (NITE BP-775) or a culture of the cell, or an extract thereof, as an active ingredient.   
     
     
         2 . A food, comprising:
 a lactic acid bacterial cell of one or more kinds selected from the group consisting of  Lactobacillus rhamnosus  strain KO3 (NITE BP-771),  Lactobacillus casei  strain YU3 (NITE BP-772) and  Lactobacillus paracasei  strain YU4 (NITE BP-775) or a culture of the cell, or an extract thereof.   
     
     
         3 . The food according to  claim 2 , which is a fermented milk or a fermented beverage. 
     
     
         4 . An agent for suppression of proliferation of a cariogenic bacterium, a periodontal disease bacterium and a candida bacterium, comprising:
 a lactic acid bacterial cell of one or more kinds selected from the group consisting of  Lactobacillus rhamnosus  strain KO3 (NITE BP-771),  Lactobacillus casei  strain YU3 (NITE BP-772) and  Lactobacillus paracasei  strain YU4 (NITE BP-775) or a culture of the cell, or an extract thereof, as an active ingredient.   
     
     
         5 . The agent for suppression of proliferation of a cariogenic bacterium, a periodontal disease bacterium and a candida bacterium according to  claim 4 ,
 wherein the cariogenic bacterium, periodontal disease bacterium and candida bacterium are at least  Streptococcus mutans, Streptococcus sobrinus, Porphyromonas gingivalis  and  Candida albicans.      
     
     
         6 .  Lactobacillus rhamnosus  strain KO3 that has been deposited as NITE BP-771,  Lactobacillus casei  strain YU3 that has been deposited as NITE BP-772 and  Lactobacillus paracasei  strain YU4 that has been deposited as NITE BP-775, at the Patent Microorganisms Depositary of the National Institute of Technology and Evaluation. 
     
     
         7 . A lactic acid bacterial cell of one or more kinds selected from the group consisting of  Lactobacillus rhamnosus  strain KO3 (NITE BP-771),  Lactobacillus casei  strain YU3 (NITE BP-772) and  Lactobacillus paracasei  strain YU4 (NITE BP-775) or a culture of the cell, or an extract thereof, which is used as a prophylactic, ameliorating or therapeutic agent for an oral disease. 
     
     
         8 . A method for prophylaxis, amelioration or treatment of an oral disease, comprising:
 administering or ingesting a lactic acid bacterial cell of one or more kinds selected from the group consisting of  Lactobacillus rhamnosus  strain KO3 (NITE BP-771),  Lactobacillus casei  strain YU3 (NITE BP-772) and  Lactobacillus paracasei  strain YU4 (NITE BP-775) or a culture of the cell, or an extract thereof.