Biochip array with a Three-Dimensional structure

Abstract

The present invention discloses a biochip with a three-dimensional structure. The surface of the three-dimensional mesoporous layer is chemically modified to recognize labeled DNAs, proteins, peptides, saccharides, and cells. In addition, this invention also discloses a method for preparing the biochip with a three-dimensional mesoporous layer, including a blending process, a heating process, a coating process, a gelation process, a cleaning process, a drying process, and a surface modification process.

1 . A biochip with a three-dimensional structure, comprising a substrate covered with a three-dimensional structure, wherein the surface of the three-dimensional structure layer is formed by a aerogel powder, and the internal and external surface of the aerogel powder was modified by at least one specific moiety and the specific moiety comprises one selected from the group consisting of the following: amine group, hydroxyl group, carboxyl group, and epoxy group. 
     
     
         2 . The biochip according to  claim 1 , wherein the specific surface area of the aerogel powder is more than or equal to 100 m 2 /g. 
     
     
         3 . The biochip according to  claim 1 , wherein the average pore diameter of the aerogel powder is less than or equal to 20 nm. 
     
     
         4 . The biochip according to  claim 1 , wherein the porosity of the aerogel powder ranges about 50% to 99%. 
     
     
         5 . The biochip according to  claim 1 , wherein the diameter of the aerogel powder ranges about 10 nm to 250 nm.