Substituted pyridinone-pyridinyl compounds

Abstract

The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.

1 . A compound having the structure of Formula (I): 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, wherein: 
         X and Y are independently selected from the group consisting of CH and N, with the proviso that when X is CH, Y is N, and when X is N, Y is CH; 
         R 1  is selected from the group consisting of C 1 -C 6 -alkyl, halo and —H; 
         R 2  is selected from the group consisting of alkyl and alkoxy; wherein the alkyl or alkoxy is optionally substituted with one or more substituents independently selected from the group consisting of cycloalkyl, aryl, and heterocyclyl; and wherein the cycloalkyl or aryl is optionally substituted with one or more substituents independently selected from the group consisting of alkyl, alkoxy and halo; and wherein the heterocyclyl is optionally substituted with one or more substituents independently selected from the group consisting of alkyl, alkoxy and cyano; 
         R 3  and R 4  are independently selected from the group consisting of alkyl, halo and —H; and 
         R 5  is selected from the group consisting of cycloalkyl, aryl, and heterocyclyl; wherein the cycloalkyl or aryl is optionally substituted with one or more substituents independently selected from the group consisting of halo, cyano, alkyl, hydroxyalkyl, alkoxyalkyl and aminoalkyl; and wherein the heterocyclyl is optionally substituted with one or more substituents independently selected from the group consisting of cyano, alkyl, hydroxyalkyl, alkoxyalkyl and aminoalkyl. 
       
     
     
         2 . The compound according to  claim 1 , wherein X is CH and Y is N. 
     
     
         3 . The compound according to  claim 2 , wherein:
 R 1  is selected from the group consisting of C 1 -C 3 -alkyl, bromo, chloro and fluoro;   R 2  is alkoxy, optionally substituted with one or more heterocyclyl substituents optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and cyano;   R 3  is C 1 -C 3 -alkyl;   R 4  is selected from the group consisting of —H, C 1 -C 3 -alkyl, bromo, chloro and fluoro; and   R 5  is heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of alkyl, hydroxyalkyl and aminoalkyl.   
     
     
         4 . The compound according to  claim 3 , wherein:
 R 1  is methyl, bromo or chloro;   R 2  is alkoxy optionally substituted with five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from C 1 -C 3 -alkyl;   R 3  is methyl;   R 4  is —H, methyl or chloro; and   R 5  is five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         5 . The compound according to  claim 4 , wherein:
 R 2  is alkoxy substituted with five-membered heteroaryl optionally substituted with one or more methyl substituents; and   R 5  is pyridine or pyrimidine, wherein the pyridine or pyrimidine is optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         6 . The compound according to  claim 5 , wherein the compound has the structure of Formula (II): 
       
         
           
           
               
               
           
         
         wherein:
 R 1  is methyl, bromo or chloro; 
 R 4  is —H, methyl or chloro; 
 R 20  is five-membered heteroaryl optionally substituted with one or more methyl substituents; 
 R 50  is —H or methyl; and 
 R 51  is —H, methyl or hydroxy. 
 
       
     
     
         7 . The compound according to  claim 6 , selected from the group consisting of:
 2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one; and   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one.   
     
     
         8 . The compound according to  claim 6 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one; and   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one.   
     
     
         9 . The compound according to  claim 6 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one; and   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one.   
     
     
         10 . A compound according to  claim 6 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one; and   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,4′-bipyridin]-2-one.   
     
     
         11 . The compound according to  claim 6 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one; and   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((5-methylthiophen-3-yl)methoxy)-2H-[1,4′-bipyridin]-2-one.   
     
     
         12 . The compound according to  claim 1 , wherein X is N and Y is CH. 
     
     
         13 . The compound according to  claim 12 , wherein:
 R 1  is selected from the group consisting of C 1 -C 3 -alkyl, bromo, chloro and fluoro;   R 2  is alkoxy, optionally substituted with one or more heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and cyano;   R 3  and R 4  are independently selected from the group consisting of —H and C 1 -C 3 -alkyl; and   R 5  is heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of alkyl, hydroxyalkyl and aminoalkyl.   
     
     
         14 . The compound according to  claim 13 , wherein:
 R 1  is methyl or chloro;   R 2  is alkoxy optionally substituted with five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from C 1 -C 3 -alkyl;   R 3  is methyl;   R 4  is —H or methyl; and   R 5  is five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         15 . The compound according to  claim 14 , wherein:
 R 2  is alkoxy substituted with five-membered heteroaryl optionally substituted with one or more methyl substituents; and   R 5  is pyridine or pyrimidine, wherein the pyridine or pyrimidine is optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         16 . The compound according to  claim 15 , wherein the compound has the structure of Formula (III): 
       
         
           
           
               
               
           
         
         wherein:
 R 1  is methyl or chloro; 
 R 4  is —H or methyl; 
 R 20  is five-membered heteroaryl optionally substituted with one or more methyl substituents;
 and 
 
 R 51  is methyl or hydroxy. 
 
       
     
     
         17 . The compound according to  claim 16 , selected from the group consisting of:
 5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2′,3,6-trimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2′,3,6-trimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2′,3,6-trimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   3-chloro-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   3-chloro-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   3-chloro-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   3-chloro-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   3-chloro-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   3-chloro-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   5′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-2′,6-dimethyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   5′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-2′,6-dimethyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   5′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-2′,6-dimethyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   5′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-6-methyl-4-((2-methyloxazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one;   5′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-6-methyl-4-((2-methylthiazol-4-yl)methoxy)-2H-[1,3′-bipyridin]-2-one; and   5′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-6-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-2H-[1,3′-bipyridin]-2-one.   
     
     
         18 . The compound according to  claim 2 , wherein:
 R 1  is selected from the group consisting of C 1 -C 3 -alkyl, bromo, chloro and fluoro;   R 2  is alkoxy, optionally substituted with one or more substituents selected from the group consisting of cycloalkyl and aryl; wherein the cycloalkyl or aryl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and halo;   R 3  and R 4  are independently C 1 -C 3 -alkyl, halo and —H; and   R 5  is heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of alkyl, hydroxyalkyl and aminoalkyl.   
     
     
         19 . The compound according to  claim 18 , wherein:
 R 1  is methyl, bromo or chloro;   R 2  is alkoxy optionally substituted with five- or six-membered aryl optionally substituted with one or more halo substituents;   R 3  is methyl;   R 4  is —H, chloro or methyl; and   R 5  is five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         20 . The compound according to  claim 19 , wherein:
 R 2  is alkoxy substituted with phenyl optionally substituted with one or more substituents independently selected from the group consisting of chloro and fluoro; and   R 5  is pyridine or pyrimidine, wherein the pyridine or pyrimidine is optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         21 . The compound according to  claim 20 , wherein the compound has the structure of Formula
 (IV):   
       
         
           
           
               
               
           
         
         wherein:
 R 1  is methyl, bromo or chloro; 
 R 4  is —H, chloro or methyl; 
 R 50  is —H or methyl; and 
 R 51  is —H, methyl or hydroxy. 
 
       
     
     
         22 . The compound according to  claim 21 , selected from the group consisting of:
 4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2″-(2-hydroxypropan-2-yl)-5′,6-dimethyl-2H-[1,4′:2′,4″-terpyridin]-2-one; and   2″-(tert-butyl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,4′:2′,4″-terpyridin]-2-one.   
     
     
         23 . The compound according to  claim 21 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((2,4-difluorobenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((2,4-difluorobenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-4-((2,4-difluorobenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((2,4-difluorobenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((2,4-difluorobenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((2,4-difluorobenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-4-((2,4-difluorobenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((2,4-difluorobenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   4-((2,4-difluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one; and   4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one.   
     
     
         24 . The compound according to  claim 1 , wherein X is N and Y is CH. 
     
     
         25 . The compound according to  claim 24 , wherein:
 R 1  is selected from the group consisting of C 1 -C 3 -alkyl, bromo, chloro and fluoro;   R 2  is alkoxy optionally substituted with one or more substituents selected from the group consisting of cycloalkyl and aryl; wherein the cycloalkyl or aryl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and halo;   R 3  and R 4  are independently C 1 -C 3 -alkyl and —H; and   R 5  is heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of alkyl, hydroxyalkyl and aminoalkyl.   
     
     
         26 . The compound according to  claim 25 , wherein:
 R 1  is methyl or chloro;   R 2  is alkoxy optionally substituted with phenyl optionally substituted with one or more halo substituents;   R 3  is methyl;   R 4  is —H or methyl; and   R 5  is five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         27 . The compound according to  claim 26 , wherein:
 R 2  is alkoxy substituted with phenyl optionally substituted with one or more substituents independently selected from the group consisting of chloro and fluoro; and   R 5  is pyridine or pyrimidine, wherein the pyridine or pyrimidine is optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         28 . The compound according to  claim 27 , wherein the compound has the structure of Formula (V): 
       
         
           
           
               
               
           
         
         wherein:
 Z is selected from the group consisting of CH and N; 
 R 1  is methyl or chloro; 
 R 4  is —H or methyl; and 
 R 51  is methyl or hydroxy. 
 
       
     
     
         29 . The compound according to  claim 28 , selected from the group consisting of:
 4-((2,4-difluorobenzyl)oxy)-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-2H-[1,3′-bipyridin]-2-one;   4-((2,4-difluorobenzyl)oxy)-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2′,3,6-trimethyl-2H-[1,3′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-2H-[1,3′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-5′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2′,6-dimethyl-2H-[1,3′-bipyridin]-2-one;   5′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,3′-bipyridin]-2-one;   5′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-2′,6-dimethyl-2H-[1,3′-bipyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2″-(2-hydroxypropan-2-yl)-6-methyl-2H-[1,3′:5′,4″-terpyridin]-2-one;   3-chloro-4-((2,4-difluorobenzyl)oxy)-2″-(2-hydroxypropan-2-yl)-2′,6-dimethyl-2H-[1,3′:5′,4″-terpyridin]-2-one;   2″-(tert-butyl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-6-methyl-2H-[1,3′:5′,4″-terpyridin]-2-one; and   2″-(tert-butyl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-2′,6-dimethyl-2H-[1,3′:5′,4″-terpyridin]-2-one.   
     
     
         30 . The compound according to  claim 1 , wherein:
 X and Y are independently selected from the group consisting of CH and N, with the proviso that when X is CH, Y is N, and when X is N, Y is CH;   R 1  is selected from the group consisting of C 1 -C 3 -alkyl, bromo, chloro and fluoro;   R 2  is alkoxy, optionally substituted with one or more substituents selected from the group consisting of cycloalkyl and aryl; wherein the cycloalkyl or aryl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and halo;   R 3  and R 4  are independently C 1 -C 3 -alkyl, halo and —H; and   R 5  is heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of alkyl, hydroxyalkyl and aminoalkyl.   
     
     
         31 . The compound according to  claim 30 , wherein:
 R 1  is methyl, bromo or chloro;   R 2  is alkoxy optionally substituted with phenyl optionally substituted with one or more halo substituents;   R 3  is methyl;   R 4  is —H, chloro or methyl; and   R 5  is five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         32 . The compound according to  claim 31 , wherein:
 R 2  is alkoxy substituted with phenyl optionally substituted with one or more substituents independently selected from the group consisting of chloro and fluoro; and   R 5  is pyridine or pyrimidine, wherein the pyridine or pyrimidine is optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         33 . The compound according to  claim 32 , wherein the compound has the structure of Formula (VI): 
       
         
           
           
               
               
           
         
         wherein:
 X and Y are independently selected from the group consisting of CH and N, with the proviso that when X is CH, Y is N, and when X is N, Y is CH; 
 R 1  is methyl, bromo or chloro; 
 R 4  is —H, chloro or methyl; 
 R 50  is —H or methyl; and 
 R 51  is —H, methyl or hydroxy. 
 
       
     
     
         34 . The compound according to  claim 33 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((4-fluorobenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((4-fluorobenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((4-fluorobenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-4-((4-fluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-4-((4-fluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-4-((4-fluorobenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((4-fluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((4-fluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((4-fluorobenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((4-fluorobenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-4-((4-fluorobenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((4-fluorobenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-4-((4-fluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-4-((4-fluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-4-((4-fluorobenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((4-fluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-4-((4-fluorobenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((4-fluorobenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((4-fluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   4-((4-fluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((4-fluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   4-((4-fluorobenzyl)oxy)-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((4-fluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   4-((4-fluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((4-fluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   4-((4-fluorobenzyl)oxy)-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-2H-[1,4′-bipyridin]-2-one; and   4-((4-fluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one.   
     
     
         35 . A compound according to  claim 1 , wherein:
 X and Y are independently selected from the group consisting of CH and N, with the proviso that when X is CH, Y is N, and when X is N, Y is CH;   R 1  is selected from the group consisting of C 1 -C 3 -alkyl, bromo, chloro and fluoro;   R 2  is alkoxy, optionally substituted with one or more substituents selected from the group consisting of cycloalkyl and aryl; wherein the cycloalkyl or aryl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy;   R 3  and R 4  are independently C 1 -C 3 -alkyl, halo and —H; and   R 5  is heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of alkyl, hydroxyalkyl and aminoalkyl.   
     
     
         36 . The compound according to  claim 35 , wherein:
 R 1  is methyl, bromo or chloro;   R 2  is alkoxy optionally substituted with phenyl optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy;   R 3  is methyl;   R 4  is —H, chloro or methyl; and   R 5  is five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         37 . A compound according to  claim 36 , wherein:
 R 2  is alkoxy substituted with phenyl optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy; and   R 5  is pyridine or pyrimidine, wherein the pyridine or pyrimidine is optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         38 . The compound according to  claim 37 , wherein the compound has the structure of Formula (VII): 
       
         
           
           
               
               
           
         
         wherein:
 X and Y are independently selected from the group consisting of CH and N, with the proviso that when X is CH, Y is N, and when X is N, Y is CH; 
 R 1  is methyl, bromo or chloro; 
 R 4  is —H, chloro or methyl; 
 R 21  is methyl or methoxy; 
 R 50  is —H or methyl; and 
 R 51  is —H, methyl or hydroxy. 
 
       
     
     
         39 . The compound according to  claim 38 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one; and   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((3-methylbenzyl)oxy)-2H-[1,4′-bipyridin]-2-one.   
     
     
         40 . The compound according to  claim 38 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-6-methyl-2H-[1,4′-bipyridin]-2-one; and   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((3-methoxybenzyl)oxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one.   
     
     
         41 . The compound according to  claim 1 , wherein:
 X and Y are independently selected from the group consisting of CH and N, with the proviso that when X is CH, Y is N, and when X is N, Y is CH;   R 1  is selected from the group consisting of C 1 -C 3 -alkyl, bromo, chloro and fluoro;   R 2  is alkoxy, optionally substituted with one or more heterocyclyl substituents optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl, C 1 -C 3 -alkoxy and cyano;   R 3  is C 1 -C 3 -alkyl;   R 4  is selected from the group consisting of —H, C 1 -C 3 -alkyl, bromo, chloro and fluoro; and   R 5  is heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of alkyl, hydroxyalkyl and aminoalkyl.   
     
     
         42 . The compound according to  claim 41 , wherein:
 R 1  is methyl, bromo or chloro;   R 2  is alkoxy optionally substituted with five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy;   R 3  is methyl;   R 4  is —H, methyl or chloro; and   R 5  is five- or six-membered heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         43 . The compound according to  claim 42 , wherein:
 R 2  is alkoxy substituted with six-membered heteroaryl optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 3 -alkyl and C 1 -C 3 -alkoxy; and   R 5  is pyridine or pyrimidine, wherein the pyridine or pyrimidine is optionally substituted with one or more substituents independently selected from the group consisting of alkyl and hydroxyalkyl.   
     
     
         44 . The compound according to  claim 43 , wherein the compound has the structure of Formula
 (VIII):   
       
         
           
           
               
               
           
         
         wherein:
 X and Y are independently selected from the group consisting of CH and N, with the proviso that when X is CH, Y is N, and when X is N, Y is CH; 
 R 1  is methyl, bromo or chloro; 
 R 4  is —H, methyl or chloro; 
 R 21  is methyl or methoxy; 
 R 50  is —H or methyl; and 
 R 51  is —H, methyl or hydroxy. 
 
       
     
     
         45 . The compound according to  claim 44 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,5′,6-trimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-5′,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,5′,6-trimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-6-methyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one; and 2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-3,6-dimethyl-4-((6-methylpyridin-2-yl)methoxy)-2H-[1,4′-bipyridin]-2-one.   
     
     
         46 . The compound according to  claim 44 , selected from the group consisting of:
 3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3,5′-dichloro-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-5′-chloro-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3,5′-dichloro-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-5′-chloro-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-3-chloro-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(tert-butyl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-isopropyl-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,5′,6-trimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3,5′-dichloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   5′-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one;   3-bromo-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one;   3-chloro-2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-6-methyl-2H-[1,4′-bipyridin]-2-one; and   2′-(2-(2-hydroxypropan-2-yl)-5-methylpyrimidin-4-yl)-4-((6-methoxypyridin-2-yl)methoxy)-3,6-dimethyl-2H-[1,4′-bipyridin]-2-one.   
     
     
         47 . A compound of 3-chloro-4-((2,4-difluorobenzyl)oxy)-2′-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one, or a pharmaceutically acceptable salt thereof. 
     
     
         48 . A compound of 2′-(2-(tert-butyl)pyrimidin-4-yl)-3-chloro-4-((2,4-difluorobenzyl)oxy)-5′,6-dimethyl-2H-[1,4′-bipyridin]-2-one, or a pharmaceutically acceptable salt thereof. 
     
     
         49 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of  claim 1  or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 
     
     
         50 . The pharmaceutical composition of  claim 49 , further comprising a therapeutically effective amount of an active pharmaceutical ingredient selected from the group consisting of anti-inflammatory drugs, anti-atherosclerotic drugs, immunosuppressive drugs, immunomodulatory drugs, cytostatic drugs, angiogenesis inhibitors, kinase inhibitors, cytokine blockers and inhibitors of cell adhesion molecules. 
     
     
         51 . A method for treating a condition comprising administering to a subject in need thereof a therapeutically effective amount of a compound of  claim 1  or pharmaceutically acceptable salt thereof, wherein the condition is selected from the group consisting of autoimmune disorders, chronic inflammatory disorders, acute inflammatory disorders, auto-inflammatory disorders, atherosclerosis, diabetes, fibrotic diseases, metabolic disorders, cancer, neoplasia, leukemia and lymphoma. 
     
     
         52 . The method of  claim 51 , wherein the subject is a mammal selected from a canine and a humane. 
     
     
         53 . The method of  claim 52 , wherein the condition is lymphoma.