Novel complexes of fatty acid esters of polyhydroxyalkanes and pyridine carboxy derivatives

Abstract

The present invention relates to novel combinations of fatty acid derivatives and pyridine carboxy derivatives, including fatty acid esters with glycerol and 3-carboxy pyridine derivates such as niacinamide. Such combinations have surprisingly shown antiviral and anti-microbial activity and the use for the treatment of inflammatory conditions and infections is disclosed herein.

1 - 62 . (canceled) 
     
     
         63 . A method for the treatment of a disease associated with hypersensitivity and/or inflammatory reactions, said method comprising the administration of
 i) glyceryl monocaprylate or an alkali metal salt thereof and   ii) niacinamide or a salt thereof,   
       wherein said disease is selected from the group consisting of hypersensitivity skin disease, pruritus, urticaria, atopic eczema, contact dermatitis, seborrhoeic dermatitis, acne, rosacea, alopecia, vitiligo, and psoriasis. 
     
     
         64 . The method according to  claim 63 , wherein said disease is seborrhoeic dermatitis. 
     
     
         65 . The method according to  claim 63 , wherein the component (i) is racemic, enantiomerically enriched or enantiomerically pure 1-glyceryl-monocaprylate. 
     
     
         66 . The method according to  claim 63 , wherein the component (ii) is niacinamide. 
     
     
         67 . The method according to  claim 63 , wherein said combination further comprises one or more therapeutically active agents. 
     
     
         68 . The method according to  claim 63 , wherein the combination is formulated for oral, topical, transdermal, or parenteral administration. 
     
     
         69 . The method according to  claim 68 , wherein the combination is formulated for topical administration. 
     
     
         70 . The method according to  claim 63 , wherein the component (i) and the component (ii) are present in a molar ratio of between about 1:3 to 1:16. 
     
     
         71 . The method according to  claim 70 , wherein the component (i) and the component (ii) are present in a molar ratio of about 1:14 or about 2:7. 
     
     
         72 . The method according to  claim 65 , wherein the component (ii) is niacinamide.