Compositions and methods for vaccinating cattle

Abstract

The present invention relates to compositions, uses thereof, and methods of vaccinating cattle, particularly cows and heifers, against Leptospira borgpetersenii serovar hardjo (type hardjo - bovis ) by using Leptospira interrogans serovar hardjo (type hardjoprajitno ).

1 . An immungenic composition comprising a  Leptospira interrogans  serovar  hardjo  (type  hardjoprajitno ) capable of provoking an immune response against  Leptospira borgpetersenii  serovar  hardjo  (type  hardjo - bovis ). 
     
     
         2 . The immunogenic composition of  claim 1 , wherein the  Leptospira interrogans  serovar  hardjo  (type  hardjoprajitno ) is a killed bacterium. 
     
     
         3 . The immunogenic composition of  claim 1 , further comprising one or more modified live viruses (MLVs) selected from the group consisting of Infectious Bovine Rhinotracheitis (IBR) virus, Bovine Virus Diarrhea (BVD) Types 1 and 2, Parainfluenza 3 (PI3) virus, and Bovine Respiratory Syncytial Virus (BRSV). 
     
     
         4 . The immunogenic composition of  claim 1 , wherein the immune response provides protection against, reduction in the incidence, and/or lessens the severity of infection by  Leptospira borgpetersenii  serovar  hardjo  (type  hardjo - bovis ) in a subject. 
     
     
         5 . The immunogenic composition of  claim 4 , wherein the subject is a bovine. 
     
     
         6 . The immunogenic composition of  claim 5 , wherein the bovine is a cow or heifer. 
     
     
         7 . A vaccine comprising a  Leptospira interrogans  serovar  hardjo  (type  hardjoprajitno ) capable of provoking a protective immune response against  Leptospira borgpetersenii  serovar  hardjo  (type  hardjo - bovis ). 
     
     
         8 . The vaccine of  claim 7 , wherein the  Leptospira interrogans  serovar  hardjo  (type  hardjoprajitno ) is a killed bacterium. 
     
     
         9 . The immunogenic composition of  claim 7 , further comprising one or more modified live viruses (MLVs) selected from the group consisting of Infectious Bovine Rhinotracheitis (IBR) virus, Bovine Virus Diarrhea (BVD) Types 1 and 2, Parainfluenza 3 (PI3) virus, and Bovine Respiratory Syncytial Virus (BRSV). 
     
     
         10 . The immunogenic composition of  claim 7 , wherein the immune response provides protection against, reduction in the incidence, and/or lessens the severity of infection by  Leptospira borgpetersenii  serovar  hardjo  (type  hardjo - bovis ) in a subject. 
     
     
         11 . The immunogenic composition of  claim 10 , wherein the subject is a bovine. 
     
     
         12 . The immunogenic composition of  claim 11 , wherein the bovine is a cow or heifer. 
     
     
         13 . A method of providing protection against, reduction in the incidence, and/or lessening the severity of infection by  Leptospira borgpetersenii  serovar  hardjo  (type  hardjo - bovis ) in a subject comprising administering to the subject an immunogenic composition, wherein the immunogenic composition includes a  Leptospira interrogans  serovar  hardjo  (type  hardjoprajitno ). 
     
     
         14 . The method of  claim 13 , wherein the  Leptospira interrogans  serovar  hardjo  (type  hardjoprajitno ) is a killed bacterium. 
     
     
         15 . The method of  claim 13 , further comprising one or more modified live viruses (MLVs) selected from the group consisting of Infectious Bovine Rhinotracheitis (IBR) virus, Bovine Virus Diarrhea (BVD) Types 1 and 2, Parainfluenza 3 (PI3) virus, and Bovine Respiratory Syncytial Virus (BRSV). 
     
     
         16 . The method of  claim 13 , wherein the immune response provides protection against, reduction in the incidence, and/or lessens the severity of infection by  Leptospira borgpetersenii  serovar  hardjo  (type  hardjo - bovis ) in a subject. 
     
     
         17 . The method of  claim 16 , wherein the subject is a bovine. 
     
     
         18 . The method of  claim 17 , wherein the bovine is a cow or heifer.