Composition for restoration of age related tissue in the face or selected areas of the body

Abstract

A treatment method for restoring of age related tissue loss in the face or selected areas of the body is disclosed which includes injecting an injectable composition containing a growth factor and hyaluronic acid as a carrier into the dermis, the hypodermis, or both, in various areas of the face, or selected areas of the body of a person to stimulate collagen, elastin, or fat cell production, thereby restoring age related tissue loss in the face and selected areas of the body. Further disclosed is an injectable composition for restoring of age related tissue loss in the face and selected areas of the body, which contains a growth factor and hyaluronic acid as a carrier for providing time release of the growth factor into tissues. The growth factor can be insulin, insulin-like growth factor, thyroid hormone, fibroblast growth factor, estrogen, retinoic acid, or their combinations.

1 - 7 . (canceled) 
     
     
         8 . An injectable composition for restoring tissue volume, skin turgor, texture and tightness in the face or selected areas of the body of a person, comprising liothyronine sodium, levothyroxine sodium, insulin, hyaluronic acid, and deuterium-reduced water. 
     
     
         9 . A two-layer injection treatment system for restoring tissue volume, skin turgor, texture and tightness in the face or selected areas of the body of a person, comprising:
 a first injectable composition for injection into the dermis, comprising an estrogen and hyaluronic acid; and   a second injectable composition for injection into the subcutaneous tissue, comprising liothyronine sodium, levothyroxine sodium, insulin, and hyaluronic acid,   wherein said hyaluronic acid in said first and second injectable compositions is effective to provide timed release for said estrogen, liothyronine sodium, levothyroxine sodium, and insulin.   
     
     
         10 . The system of  claim 9 , wherein said first and said second injectable compositions further comprise retinoic acid. 
     
     
         11 . The system of  claim 9 , wherein said estrogen comprises estriol, estradiol, estrone or combinations thereof. 
     
     
         12 . The system of  claim 9 , wherein said estrogen is estriol. 
     
     
         13 . The system of  claim 12 , wherein said estriol has a concentration from 0.02 g to 0.2 g per 100 ml of said composition. 
     
     
         14 . The system of  claim 9 , wherein said second injectable composition comprises 2 μg to 30 μg of liothyronine sodium, 10 μg to 60 μg of levothyroxine sodium, 5 units to 40 units of insulin, and 0.5 g to 3 g of hyaluronic acid, per 100 ml of said second injectable composition.