Wear resistant antimicrobial compositions and methods of use

Abstract

Anti-microbial compositions comprising (a) a quaternary ammonium compound and (b) a cationic biocide. Applicant has discovered a synergistic combination of the two components with the ration of cationic biocide to quaternary ammonium being less than 1:10 or with a single quaternary compound in a ratio of less than 1.6 to 1 provide a film forming coating that has residual anti-bacterial activity and improved durability with strong resistance to general wear between applications.

1 . An anti-microbial composition comprising:
 a quaternary ammonium compound; and   a cationic biocide, wherein the amount of cationic biocide is less than 1 to 10 in a ratio of cationic biocide to quaternary ammonium on an actives weight basis.   
     
     
         2 . The anti-microbial composition of  claim 1  wherein the ratio of cationic biocide to quaternary ammonium is from about 1:2.5 to about 1:6.25 
     
     
         3 . The anti-microbial composition of  claim 1  wherein said ratio of cationic biocide to quaternary ammonium is from about 1:1 to 1:6.25. 
     
     
         4 . The anti-microbial composition of  claim 1  wherein said ratio of cationic biocide to quaternary ammonium is from about 1:0.625 to 1:10. 
     
     
         5 . The anti-microbial composition of  claim 1  wherein said quaternary ammonium compound is in an amount of about 975 to about 6250 ppm. 
     
     
         6 . The c anti-microbial composition of  claim 1  wherein said cationic biocide is in an amount of about 156 to about 2500 ppm. 
     
     
         7 . The anti-microbial composition of  claim 1  wherein said cationic biocide is polyhexmethylene biguanide (PHMB). 
     
     
         8 . The anti-microbial composition of  claim 1  wherein said quaternary ammonium compound is quaternary ammonium chloride. 
     
     
         9 . The anti-microbial composition of  claim 1  wherein said composition comprises more than one quaternary ammonium compound. 
     
     
         10 . An anti-microbial composition comprising:
 quaternary ammonium compound; a cationic biocide, an amine oxide surfactant, and a chelant.   
     
     
         11 . The anti-microbial composition of  claim 10  wherein the ratio of quaternary ammonium to surfactant is from about 2:1 to about 7:1 respectively. 
     
     
         12 . The anti-microbial composition of  claim 10  wherein the ratio of quaternary ammonium compound to chelant is from about 2:1 to about 3.5 to 1 respectively. 
     
     
         13 . The anti-microbial composition of  claim 10  wherein said amine oxide has a carbon chain length of 8 or less. 
     
     
         14 . The anti-microbial composition of  claim 10  wherein said chelant is EDTA. 
     
     
         15 . The anti-microbial composition of  claim 10  wherein said composition comprises from about 1:25% to about 50% wt. % of quaternary ammonium compound, from about 0.125% to about 8.0% of cationic biocide, from about 0.4% to about 12.8 wt. % of amine oxide, and from about 0.4% to about 12.8% chelant. 
     
     
         16 . The composition of  claim 15  wherein said concentrate is diluted to a use composition at a ratio of about 1:64. 
     
     
         17 . The use solution of  claim 16  wherein said solution comprises from about 195 ppm to about 7800 ppm of quaternary ammonium compound, from about 19.5 ppm to about 1250 ppm of cationic biocide, from about 62.5 to about 2000 ppm amine oxide, and from about 62.5 to about 2000 ppm chelant. 
     
     
         18 . The anti-microbial composition of  claim 10  wherein said cationic biocide is polyhexmethylene biguanide (PHMB). 
     
     
         19 . The anti-microbial composition of  claim 1  wherein said quaternary ammonium compound is quaternary ammonium chloride. 
     
     
         20 . The anti-microbial composition of  claim 1  wherein said composition provides mild to non-eye irritancy. 
     
     
         21 . The antimicrobial composition of  claim 1  wherein said composition provides wet and dry efficacy. 
     
     
         22 . The antimicrobial composition of  claim 1  wherein said composition is optimized for non-eye irritancy, with wet and dry efficacy and reduction in microbial contamination. 
     
     
         23 . The composition of  claim 1  wherein said composition provides 99.9% log reduction in microbial contamination following a 24 wear cycles abrasion challenge. 
     
     
         24 . A method of disinfecting a surface comprising:
 Applying the disinfectant solution to a surface cleaning, providing wet disinfection and   applying a protective coating to the said surface a composition according to  claim 10 , so that a film is formed on said surface that continues to reduce microbial contamination after general wear for an extended period of time.   
     
     
         25 . A method according to  claim 20  wherein the film provides a 99% reduction of  Pseudomonas aeruginosa  and  Staphylococcus aureus  following 30 abrasive wear cycles. 
     
     
         26 . The method of  claim 24  wherein said antimicrobial composition provides mild to non-eye irritancy. 
     
     
         27 . The method of  claim 24  wherein said antimicrobial composition of  claim 24  wherein said composition provides wet and dry efficacy. 
     
     
         28 . The method of  claim 24  wherein said composition is optimized for non-eye irritancy, with wet and dry efficacy and reduction in microbial contamination. 
     
     
         29 . The method of  claim 24  wherein said composition provides 99.9% log reduction in microbial contamination following a 24 wear cycle abrasion challenge. 
     
     
         30 . A method of making an anti-microbial composition that is non-eye-irritating, and provides both wet and dry efficacy comprising:
 mixing a solution comprising:   a quaternary ammonium compound;   a cationic biocide,   an amine oxide surfactant, and   a chelant wherein the ratio of quaternary ammonium to surfactant is from about 2:1 to about 7:1 respectively.   
     
     
         31 . The method of  claim 30  wherein said amine oxide has a carbon chain length of 8 or less.