Anti-jam-a antibodies

Abstract

The present invention relates to novel isolated antibodies, derived compounds, and functional isolated antibody fragments, capable of inhibiting the proliferation of tumor cells in vitro and/or in vivo and obtained by functional screening. More particularly, the present invention relates to the 6F4 antibody, specific to the JAM-A protein, as well as its use for the treatment of cancer. Pharmaceutical compositions composed of these antibodies are also covered.

1 . A method for preventing or treating a disease related to tumor cell proliferation in a mammal comprising administering to said mammal an antibody or a derived compound or functional fragment of said antibody, wherein said antibody, derived compound, or functional fragment comprises at least one complementarity-determining region (“CDR”) and wherein said at least one CDR comprises SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, or a combination thereof. 
     
     
         2 . The method according to  claim 1 , wherein said disease related to tumor cells proliferation is cancer. 
     
     
         3 . The method according to  claim 2 , wherein said cancer is a cancer selected from the group consisting of prostate cancer, osteosarcoma, lung cancer, breast cancer, endometrial cancer, multiple myeloma, ovarian cancer, pancreatic cancer, and colon cancer. 
     
     
         4 . The method according to  claim 3 , wherein said cancer is a cancer selected from the group consisting of estrogen-related breast cancer, non-small cell lung cancer, colon cancer, and pancreatic cancer.