Infection-resistant polyurethane foams, method for producing the same and use thereof in antiseptic wound dressing

Abstract

The present invention describes microbicidal hydrophilic polyurethane foams endowed with polyhexamethylenebiguanide (PHMB) and/or its hydrochloride and also a superabsorbent, wound contact materials obtainable therefrom and processes for producing the therapeutically endowed polyurethane foams and the wound contact materials obtainable therefrom.

1 . A cellular hydrophilic polyurethane gel containing an antiseptic agent polyhexamethylenebiguanide and/or a hydrochloride thereof and a superabsorbent, wherein the antiseptic agent is present in the polyurethane gel as a microparticulate dispersion and/or homogenous solution. 
     
     
         2 . A process for producing the cellular hydrophilic polyurethane gel according to  claim 1  by reaction of monomers and a foaming agent in the presence of any desired active, wherein at least one active is mixed into a mixture of the monomers before polymerization. 
     
     
         3 . A method for producing medical equipment comprising:
 obtaining cellular hydrophilic polyurethane gel according to  claim 1 ; and   using said polyurethane gel to produce said equipment.   
     
     
         4 . A method for producing an at least one-ply wound contact material comprising:
 obtaining the polyurethane gel according to  claim 1 ; and   using said polyurethane gel to produce said contact material.   
     
     
         5 . A method for producing a wound contact material for large or chronic wounds comprising:
 obtaining the polyurethane gel according to  claim 1 ; and   using said polyurethane gel to produce said contact material.   
     
     
         6 . A wound contact material comprising at least one cellular hydrophilic polyurethane gel according to  claim 1 . 
     
     
         7 . The cellular hydrophilic polyurethane gel according to  claim 1 , wherein the antiseptic agent is present as a microparticular dispersion comprising a substantially uniform dispersion of antiseptic agent, dispersed in the polyurethane gel in finely grounded or micronized form. 
     
     
         8 . The cellular hydrophilic polyurethane gel according to  claim 7 , wherein the antiseptic agent is of particle size 0.5 to 50 μm. 
     
     
         9 . The cellular hydrophilic polyurethane gel according to  claim 8 , wherein the antiseptic agent is of particle size 1 to 5 μm. 
     
     
         10 . The cellular hydrophilic polyurethane gel according to  claim 1 , wherein the antiseptic agent is of particle size 0.5 to 50 μm. 
     
     
         11 . The cellular hydrophilic polyurethane gel according to  claim 1 , wherein the antiseptic agent is of particle size 1 to 5 μm. 
     
     
         12 . The cellular hydrophilic polyurethane gel according to  claim 1 , wherein the antiseptic agent is present as a particulate dispersion. 
     
     
         13 . The cellular hydrophilic polyurethane gel according to  claim 1 , wherein the antiseptic agent is present as a homogeneous solution.