Compounds for the selective treatment of the intestinal immuno-inflammatory component of the celiac disease

Abstract

In one aspect, the present invention relates to amino-salicylic—aminophenylpropionic compounds for the use in the treatment of the inflammatory component of the celiac disease. These compounds act by blocking the cytokines released in the celiac disease and are specifically useful in the treatment of cases refractory to the diet, in dietary errors and in the reduction of the celiac disease remission time.

1 . A method of treatment of the immune-inflammation component of celiac disease in a subject comprising administering to the subject in need thereof, a therapeutically effective amount of 5-aminosalicylic acid or pharmaceutically acceptable salts or esters thereof. 
     
     
         2 . A method of treatment according to  claim 1  wherein the immune inflammation is located only at the mucosa of the duodenal portion of small intestine. 
     
     
         3 . A method of treatment according to  claim 1  wherein said subject is a refractory celiac disease subject. 
     
     
         4 . A method of treatment according to  claim 1  wherein said subject is on a diet triggered by a dietary error. 
     
     
         5 . A method of treatment of the immune inflammation component of celiac disease according to  claim 1  for shortening the clinical and/or histological remission time of the subject.