Interferon-like proteins and uses thereof

Abstract

The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IFN-L polypeptides.

1 . An antibody that specifically binds the polypeptide comprising the amino acid sequence as set forth in either SEQ ID NO: 2 or SEQ ID NO: 5, or a fragment thereof. 
     
     
         2 . The antibody of  claim 1  that is a humanized antibody. 
     
     
         3 . The antibody of  claim 1  that is a human antibody or fragment thereof. 
     
     
         4 . The antibody of  claim 1  that is a polyclonal antibody or fragment thereof. 
     
     
         5 . The antibody of  claim 1  that is a monoclonal antibody or fragment thereof. 
     
     
         6 . The antibody of  claim 1  that is a chimeric antibody or fragment thereof. 
     
     
         7 . The antibody of  claim 1  that is a CDR-grafted antibody or fragment thereof. 
     
     
         8 . The antibody of  claim 1  that is a variable region fragment. 
     
     
         9 . The variable region fragment of  claim 1  that is a Fab or a Fab′ fragment. 
     
     
         10 . The antibody of  claim 1  that is bound to a detectable label. 
     
     
         11 . A antibody produced by immunizing an animal with a polypeptide comprising an amino acid sequence of either SEQ ID NO: 2 or SEQ ID NO: 5. 
     
     
         12 . A hybridoma which produces an antibody which is capable of binding a polypeptide according to any of  claim 1 .