Bodily sealants and methods and apparatus for image-guided delivery of same

Abstract

Generally, systems, methods, and apparatus related to the use of a dynamic imaging modality in an image guided intervention are disclosed herein. More specifically, the use of such modalities in sealing a bodily opening, such as those that may be formed during an invasive medical procedure are disclosed herein. In some embodiments, a method includes viewing a representation of an instrument within a body of a patient, adjusting a position of the instrument based on the viewing such that a portion of the instrument is at a location within the body of the patient, and delivering a sealant via the instrument to the location within the body of the patient. The sealant is configured to seal an opening in the body part.

1 - 14 . (canceled) 
     
     
         15 . An apparatus, comprising: a first shaft defining a lumen and an opening in communication with the lumen of the first shaft, at least a portion of the first shaft disposable within a body of a patient; and a second shaft defining a chamber and an opening in communication with the chamber of the second shaft, the chamber of the second shaft configured to receive a sealant, the second shaft configured to be movably received within the lumen of the first shaft, the second shaft having a first position in which the opening of the second shaft is fluidically isolated from the opening of the first shaft and a second position in which the opening of the second shaft is in fluid communication with the opening of the first shaft, the opening of the first shaft and the opening of the second shaft defining a flow passageway for the sealant when the second shaft is in its second position. 
     
     
         16 . The apparatus of  claim 15 , wherein the flow passageway is configured to permit movement of the sealant from the chamber of the second shaft to a location exterior to the first shaft. 
     
     
         17 . The apparatus of  claim 15 , wherein the second shaft defines a lumen, the lumen configured to receive a medical instrument, the medical instrument being at least one of a light source, a scope, a biopsy tool, or a camera. 
     
     
         18 . The apparatus of  claim 15 , wherein the second shaft defines a lumen fluidically isolated from the chamber of the second shaft, the lumen of the second shaft configured to receive a medical instrument, the medical instrument being at least one of a light source, a scope, a biopsy tool, or a camera. 
     
     
         19 . The apparatus of  claim 15 , wherein at least one of the first shaft or the second shaft includes a reference marker, the reference marker viewable by an imaging device that is exterior the body of the patient when the reference marker is disposed within the body of the patient. 
     
     
         20 . The apparatus of  claim 15 , wherein the second shaft is movable with respect to the first shaft in at least one of a rotational direction or a translational direction. 
     
     
         21 . The apparatus of  claim 15 , wherein the first shaft includes a coating disposed on an outer surface of at least a portion of the first shaft, the coating configured to form a seal between the portion of the first shaft and a portion of the body of the patient in contact with the outer surface of the portion of the first shaft. 
     
     
         22 . The apparatus of  claim 15 , wherein the sealant includes at least one of thrombin, fibrinogen, a cyanocrylate, collagen, a cross-linker, an aldehyde, or a hydrogel. 
     
     
         23 . The apparatus of  claim 15 , further comprising: a sensor coupled to a distal end portion of at least one of the first shaft or the second shaft, the sensor configured to sense a pressure within a portion of the body of the patient in which the sensor is disposed. 
     
     
         24 - 37 . (canceled) 
     
     
         38 . An apparatus comprising: an elongate member defining a lumen, at least a portion of the elongate member configured to define an opening within a bodily tissue; and a coating disposed on at least a portion of an outer surface of the elongate member, the coating configured to form a seal between the elongate member and the bodily tissue when the elongate member is disposed within the opening of the bodily tissue. 
     
     
         39 . The apparatus of  claim 38 , wherein the coating includes at least one of thrombin, fibrinogen, a cyanocrylate, collagen, a cross-linker, an aldehyde, or a hydrogel. 
     
     
         40 . The apparatus of  claim 38 , wherein the elongate member includes a marker, the marker disposable within a body of a patient, the marker viewable by an imaging device that is exterior to the body of the patient when the marker is disposed within the body of the patient. 
     
     
         41 . The apparatus of  claim 38 , wherein the coating is configured to change from a first physical state to a second physical state different than the first physical state in response to contacting at least one of the bodily tissue, a bodily fluid, or a second coating.