Boehmeria extract and its use in treating liver diseases

Abstract

A pharmaceutical composition prepared from a Boehmeria species. This composition can be used to improve liver function and treat liver disease, and promoting liver tissue regeneration.

1 . A pharmaceutical composition prepared by an extracting process comprising:
 immersing a part of a  Boehmeria  species in water,   removing the part of the  Boehmeria  species to obtain a solution, and   concentrating the solution to provide a pharmaceutical composition,   wherein the  Boehmeria  species is the only herb subjected to the extracting process.   
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the  Boehmeria  species is  Boehmeria nivea  or  Boehmeria frustescens thunberg.    
     
     
         3 . The pharmaceutical composition of  claim 1 , wherein the immersing step is performed at a temperature between 20° C.-70° C. 
     
     
         4 . The pharmaceutical composition of  claim 3 , wherein the immersing step is performed at a temperature between 25° C.-40° C. 
     
     
         5 . The pharmaceutical composition of  claim 1 , wherein the immersing step is performed for 2-24 hours. 
     
     
         6 . The pharmaceutical composition of  claim 2 , wherein the immersing step is performed at a temperature between 20° C.-70° C. 
     
     
         7 . The pharmaceutical composition of  claim 6 , wherein the immersing step is performed at a temperature between 25° C.-40° C. 
     
     
         8 . The pharmaceutical composition of  claim 7 , wherein the immersing step is performed for 2-24 hours. 
     
     
         9 . The pharmaceutical composition of  claim 1 , wherein the extracting process further comprises enriching active components in the concentrated solution by chromatography. 
     
     
         10 . The pharmaceutical composition of  claim 9 , wherein the chromatography is column chromatography or high performance liquid chromatography. 
     
     
         11 . The pharmaceutical composition of  claim 10 , wherein the eluent used in the chromatography includes H 2 O, CH 3 CN, CH 3 OH, or a mixture thereof. 
     
     
         12 . The pharmaceutical composition of  claim 8 , wherein the extracting process further comprises enriching active components in the concentrated solution by chromatography. 
     
     
         13 . The pharmaceutical composition of  claim 12 , wherein the chromatography is column chromatography or high performance liquid chromatography. 
     
     
         14 . The pharmaceutical composition of  claim 13 , wherein the eluent used in the chromatography includes H 2 O, CH 3 CN, CH 3 OH, or a mixture thereof. 
     
     
         15 . A method of improving liver function, comprising administering to a subject in need thereof an effective amount of a pharmaceutically composition of  claim 1 . 
     
     
         16 . A method of improving liver function, comprising administering to a subject in need thereof an effective amount of a pharmaceutically composition of  claim 14 . 
     
     
         17 . A method of treating liver disease, comprising administering to a subject in need thereof an effective amount of a pharmaceutically composition of  claim 1 . 
     
     
         18 . The method of  claim 17 , wherein the liver disease is liver fibrosis, liver cirrhosis, liver inflammation, hepatitis B virus infection, hepatitis C virus infection, or liver cancer. 
     
     
         19 . A method of treating liver disease, comprising administering to a subject in need thereof an effective amount of a pharmaceutically composition of  claim 14 . 
     
     
         20 . The method of  claim 19 , wherein the liver disease is liver fibrosis, liver cirrhosis, liver inflammation, hepatitis B virus infection, hepatitis C virus infection, or liver cancer.