Spirocyclic heterocyclic derivatives and methods of their use

Abstract

Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.

1 - 148 . (canceled) 
     
     
         149 . A method for preventing or treating a urogenital tract disorder, comprising the step of:
 administering to a patient in need thereof an effective amount of a compound of the following formula:   
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or N-oxide thereof. 
     
     
         150 . A method according to  claim 149 ,
 wherein said urogenital tract disorder is incontinence or overactive bladder.   
     
     
         151 . A method according to  claim 150 , wherein said incontinence is stress urinary incontinence or urge urinary incontinence. 
     
     
         152 . A method according to  claim 150 , wherein said urogenital tract disorder is overactive bladder. 
     
     
         153 . A method according to  claim 150  further comprising the step of:
 administering to said patient an effective amount of an agent for the treatment of incontinence.