US2012165361A1PendingUtilityA1

Drug coating providing high drug loading and methods for providing the same

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Assignee: CRUZ EVANGELINEPriority: Sep 26, 2003Filed: Mar 6, 2012Published: Jun 28, 2012
Est. expirySep 26, 2023(expired)· nominal 20-yr term from priority
Inventors:Evangeline CruzGregory RuhlmannBrenda PollockSherry LiCarmelita GarciaAlfredo M. WongRyan BronzTracy FinkDavid E. Edgren
A61K 9/1676A61K 31/167A61K 9/2086A61P 29/00A61K 9/4808A61K 9/2886A61K 31/165A61K 9/0004A61K 31/485A61P 25/04A61K 9/5084A61K 31/00A61K 9/209A61K 9/28A61K 9/20A61K 9/48
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Claims

Abstract

The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.

Claims

exact text as granted — not AI-modified
1 - 11 . (canceled) 
     
     
         12 . A coating formulation that comprises
 an insoluble drug;   hydroxypropyl cellulose;   a water soluble film former comprising hydroxypropyl methylcellulose, copovidone, a film-forming agent that forms a solid solution with the insoluble drug, or blends thereof; and   an aqueous solvent.   
     
     
         13 . The coating formulation of  claim 12  comprising about 80 wt % of the aqueous solvent and about 20 wt % solids content. 
     
     
         14 . The coating formulation of  claim 12 , wherein the coating formulation further comprises a viscosity enhancer, surfactant, or a disintegrating agent. 
     
     
         15 . The coating formulation of  claim 12 , wherein the insoluble drug comprises a non-steroidal anti-inflammatory drug. 
     
     
         16 . The coating formulation of  claim 12 , wherein the insoluble drug comprises acetaminophen. 
     
     
         17 . The coating formulation of  claim 12 , wherein the coating formulation further comprises a soluble drug. 
     
     
         18 . The coating formulation of  claim 17 , wherein the soluble drug comprises an opioid. 
     
     
         19 . The coating formulation of  claim 18 , wherein the opioid comprises hydrocodone. 
     
     
         20 . The coating formulation of  claim 12 , wherein the water soluble film former comprises a blend of hydroxypropyl methylcellulose and copovidone. 
     
     
         21 . The coating formulation of  claim 12 , wherein the wt/wt ratio of copovidone to hydroxypropyl methylcellulose is about 1:1.5.

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