Anaplerotic Therapy of Huntington Disease and Other Polyglutamine Diseases

Abstract

The present invention relates to a method for treating and/or preventing Huntington disease and other polyglutamine diseases, comprising the step of administering an effective amount of a precursor of propionyl-CoA to an individual in need thereof.

1 . A method of treating and/or preventing a polyglutamine disease comprising administering a precursor of propionyl-CoA in an amount effective for treating and/or preventing a polyglutamine disease. 
     
     
         2 . The method according to  claim 1 , wherein the polyglutamine disease is Huntington disease. 
     
     
         3 . The method according to  claim 1 , wherein the precursor of propionyl-CoA is selected from the group consisting of odd-medium-chain fatty acids, seven-carbon fatty acid, triheptanoin, heptanoate, C5 ketone bodies, 3-ketovalerate and 3-hydroxyvalerate. 
     
     
         4 . The method according to  claim 1 , wherein the precursor of propionyl-CoA is triheptanoin, heptanoic acid or heptanoate. 
     
     
         5 . The method according to  claim 1 , wherein the precursor of propionyl-CoA is triheptanoin. 
     
     
         6 . The use method according to any preceding claims  claim 1 , wherein the precursor of propionyl-CoA is administered via ingestion of a food substance containing said precursor. 
     
     
         7 . The method according to  claim 2 , wherein the precursor of propionyl-CoA is selected from the group consisting of odd-medium-chain fatty acids, seven-carbon fatty acid, triheptanoin, heptanoate, C5 ketone bodies, 3-ketovalerate and 3-hydroxyvalerate. 
     
     
         8 . The method according to  claim 2 , wherein the precursor of propionyl-CoA is triheptanoin, heptanoic acid or heptanoate. 
     
     
         9 . The method according to  claim 3 , wherein the precursor of propionyl-CoA is triheptanoin, heptanoic acid or heptanoate. 
     
     
         10 . The method according to  claim 7 , wherein the precursor of propionyl-CoA is triheptanoin, heptanoic acid or heptanoate. 
     
     
         11 . The method according to  claim 2 , wherein the precursor of propionyl-CoA is triheptanoin. 
     
     
         12 . The method according to  claim 3 , wherein the precursor of propionyl-CoA is triheptanoin. 
     
     
         13 . The method according to  claim 4 , wherein the precursor of propionyl-CoA is triheptanoin. 
     
     
         14 . The method according  claim 2 , wherein the precursor of propionyl-CoA is administered via ingestion of a food substance containing said precursor. 
     
     
         15 . The method according to  claim 3 , wherein the precursor of propionyl-CoA is administered via ingestion of a food substance containing said precursor. 
     
     
         16 . The method according to  claim 4 , wherein the precursor of propionyl-CoA is administered via ingestion of a food substance containing said precursor.