novel application of fibrinogen-420 and its active domain

Abstract

The invention discloses a novel application of fibrinogen-420 and its active domain (alpha EC domain), and a separate alpha EC domain protein has the same or similar function with fibrinogen-420. Fibrinogen-420 and its active domain can be widely used in inhibiting protein aggregation, helping protein refolding, drugs which can prevent and/or treat protein conformation disease, detecting denatured protein in quality control and protect protein from denaturation.

1 . The application of inhibiting protein aggregation or refolding the denatured proteins with the following a) or b) protein;
 a) Its amino acid sequence is the sequence 1 in the sequence table;   b) Fibrinogen-420; said fibrinogen-420 prefers human fibrinogen-420.   
     
     
         2 . According to the application of  claim 1 , its characteristic lies in that the molar ratio of the described a) or b) protein and denatured protein is 25:1 to 1:100. 
     
     
         3 . The application in preparation for drugs which can prevent and/or treat protein misfolding diseases with the following a) or b) protein;
 a) Its amino acid sequence is the sequence 1 in the sequence table;   b) Fibrinogen-420; said fibrinogen-420 prefers human fibrinogen-420.   
     
     
         4 . One drug for preventing and/or treating protein conformation disease and its active ingredient is the following a) or b) protein;
 a) Its amino acid sequence is the sequence 1 in the sequence table;   b) Fibrinogen-420; said fibrinogen-420 prefers human fibrinogen-420.   
     
     
         5 . The application of protein anti-denaturation with the following a) or b) protein;
 a) Its amino acid sequence is the sequence 1 in the sequence table;   b) Fibrinogen-420; said fibrinogen-420 prefers human fibrinogen-420.   
     
     
         6 . One drug for treating protein degenerative diseases and its active ingredient is the following a) or b) protein;
 a) Its amino acid sequence is the sequence 1 in the sequence table;   b) Fibrinogen-420; said fibrinogen-420 prefers human fibrinogen-420.   
     
     
         7 . One protein stabilizing agent whose active ingredient is the following a) or b) protein;
 a) Its amino acid sequence is the sequence 1 in the sequence table;   b) Fibrinogen-420; said fibrinogen-420 prefers human fibrinogen-420.   
     
     
         8 . The application in quality control and detection of protein products with the following a) or b) protein;
 a) Its amino acid sequence is the sequence 1 in the sequence table;   b) Fibrinogen-420; said fibrinogen-420 prefers human fibrinogen-420.