Methods and devices for treatment of vascular defects

Abstract

Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments include thin permeable membranes configured to occlude blood flow therethrough.

1 . A device for treatment of a patient's vasculature, comprising:
 an expandable wire body support structure, including:
 a low profile radially constrained state with a first end, a second end, an elongated tubular configuration having a longitudinal axis, elongate flexible wires forming a plurality of openings between wires, and a first transverse dimension suitable for delivery from a microcatheter configured for navigation in cerebral vasculature, and 
 an expanded relaxed state with a substantially spherical or globular configuration having a second transverse dimension substantially greater than the first transverse dimension of the tubular configuration of the radially constrained state; and 
   a permeable layer disposed over the expandable wire body support structure which is configured to cover an aneurysm opening and having a portion with low or no porosity.   
     
     
         2 . The device of  claim 1  wherein the permeable layer comprises a braided wire occlusive mesh. 
     
     
         3 . The device of  claim 1  wherein a total volume of the permeable layer is less than about 5 mm 3 . 
     
     
         4 . The device of  claim 3  wherein the total volume of the permeable layer is between 0.5 mm 3  and 4 mm 3 . 
     
     
         5 . The device of  claim 1  wherein the permeable layer comprises wires having a thickness of less than about 0.20 mm. 
     
     
         6 . The device of  claim 5  wherein the permeable layer comprises wires having a thickness of about 0.01 mm to about 0.20 mm. 
     
     
         7 . The device of  claim 6  wherein the permeable layer comprises wires having a thickness of about 0.01 mm to about 0.10 mm. 
     
     
         8 . The device of  claim 1  wherein at least one of the support structure or permeable layer of the device comprises an open distal end. 
     
     
         9 . An aneurysm embolization device comprising:
 a wire layer forming a first wire structural layer having a substantially hollow spherical or bulbous configuration; and   a braided mesh layer attached to at least the proximal portion of the outer surface of said structural support member; and   wherein said device is adapted to be compressed for delivery through a catheter and to open upon deployment to substantially fill an aneurysm such that the braided mesh layer and wire structural layer cover a neck of an aneurysm being treated.   
     
     
         10 . The device of  claim 9  wherein the braided mesh layer comprises a braided wire occlusive mesh. 
     
     
         11 . The device of  claim 9  wherein a total volume of the braided mesh layer is less than about 5 mm 3 . 
     
     
         12 . The device of  claim 11  wherein the total volume of the braided mesh layer is between 0.5 mm 3  and 4 mm 3 . 
     
     
         13 . The device of  claim 9  wherein the braided mesh layer comprises wires having a thickness of less than about 0.20 mm. 
     
     
         14 . The device of  claim 9  wherein the braided mesh layer comprises wires having a thickness of about 0.01 mm to about 0.10 mm. 
     
     
         15 . The device of  claim 9  wherein at least one layer of the device comprises an open distal end. 
     
     
         16 . A device for treatment of a patient's vasculature, comprising:
 a support layer including:
 a low profile radially constrained state with an elongated tubular configuration that includes a first end, a second end, a longitudinal axis and elongate flexible wires disposed substantially parallel to each other with first ends thereof secured to a first ring and second ends thereof secured to a second ring with the first and second rings being disposed substantially concentric to the longitudinal axis, and a middle portion of the expandable body having a first transverse dimension with a low profile suitable for delivery from a microcatheter, and 
 an expanded relaxed state having an axially shortened configuration relative to the constrained state such that the middle portion has a second transverse dimension substantially greater than the first transverse dimension and each wire is configured to flex radially with respect to the longitudinal axis of the expandable body; and 
   a braided mesh layer disposed on the support structure when in the expanded relaxed state.   
     
     
         17 . The device of  claim 16  wherein the braided mesh layer comprises a braided wire occlusive mesh. 
     
     
         18 . The device of  claim 16  wherein a total volume of the braided mesh layer is less than about 5 mm 3 . 
     
     
         19 . The device of  claim 18  wherein the total volume of the braided mesh layer is between 0.5 mm 3  and 4 mm 3 . 
     
     
         20 . The device of  claim 16  wherein the braided mesh layer comprises wires having a thickness of less than about 0.20 mm. 
     
     
         21 . The device of  claim 20  wherein the braided mesh layer comprises wires having a thickness of about 0.01 mm to about 0.20 mm. 
     
     
         22 . The device of  claim 21  wherein the braided mesh layer comprises wires having a thickness of about 0.01 mm to about 0.10 mm. 
     
     
         23 . The device of  claim 16  wherein at least one of the support layer or braided mesh layer of the device comprises an open distal end. 
     
     
         24 . An aneurysm embolization device comprising:
 a first layer comprising a plurality of wires; and   a second layer comprising a braided mesh, the second layer being disposed along at least a portion of the first layer; and   wherein said device is adapted to be compressed for delivery through a catheter and to open, upon deployment, to substantially fill an aneurysm such that the second layer substantially covers an opening of the aneurysm.   
     
     
         25 . The device of  claim 24  wherein the second braided mesh layer comprises a braided wire occlusive mesh. 
     
     
         26 . The device of  claim 24  wherein a total volume of the second layer is less than about 5 mm 3 . 
     
     
         27 . The device of  claim 26  wherein the total volume of the second layer is between 0.5 mm 3  and 4 mm 3 . 
     
     
         28 . The device of  claim 24  wherein the second layer comprises wires having a thickness of less than about 0.20 mm. 
     
     
         29 . The device of  claim 24  wherein the second layer comprises wires having a thickness of about 0.01 mm to about 0.10 mm. 
     
     
         30 . The device of  claim 24  wherein at least one layer of the device comprises an open distal end.