Surface Modified Metal Nano-Particle and Use Thereof

Abstract

The present invention provides a metal nanoparticle that is surface-modified with a hydrophilic or hydrophobic functional group, and a composition for optical detection comprising the same. The surface-modified nanoparticles according to the present invention form clusters suitable for optical detection, for example, suitable as an X-ray contrast agent, and have surface plasmon energy in the visible region, thereby being usefully applied to a variety of optical detection methods.

1 . A surface-modified metal nanoparticle,
 wherein a surface-modifying material is introduced on its surface,   a particle diameter is 1 to 100 nanometer, and   the surface-modifying material is one or more selected from the group consisting of aliphatic or aromatic carboxylic acid having 1 to 20 carbon atoms, pyrimidine-based bases, purine-based bases, linear or branched alcohols having 1 to 10 carbon atoms, and alkyl groups having 1 to 50 carbon atoms.   
     
     
         2 . The surface-modified metal nanoparticle according to  claim 1 , wherein the metal particle is selected from the group consisting of gold, silver, magnesium oxide, iron, platinum, titanium, alumina, and zirconia. 
     
     
         3 . The surface-modified metal nanoparticle according to  claim 1 , wherein the surface-modifying material is introduced on the metal surface through a functional group selected from the group consisting of a thiol group, a carboxyl group, an amine group, an aldehyde group, a ketone group, a peroxide group, an alkene group having 3 to 500 carbon atoms, alkyl halide having 3 to 500 carbon atoms, an ester group, an ether group, an epoxide group, a nitrile group, and a carbonyl group. 
     
     
         4 . The surface-modified metal nanoparticle according to  claim 1 , wherein the surface-modifying material is one or more selected from the group consisting of linear or branched alcohols having 1 to 10 carbon atoms. 
     
     
         5 . A composition for optical detection, comprising the surface-modified metal nanoparticle according to  claim 1 . 
     
     
         6 . The composition for optical detection according to  claim 5 , comprising the surface-modified metal nanoparticle in one or more solvents selected from the group consisting of water, linear or branched alcohol having 3 to 500 carbon atoms, aldehyde having 3 to 500 carbon atoms, ketone having 3 to 500 carbon atoms, and normal paraffin-based solvent having 5 to 20 carbon atoms at a concentration of 100 ppm to 10 wt %. 
     
     
         7 . The composition for optical detection according to  claim 5 , wherein the composition is used for X-ray contrast agent, UV spectroscopy, or fluorescence analysis.