Methods for silver promoted fluorination of organic molecules

Abstract

The methods of the disclosure may be used for the fluorination of organic compounds, and in particular aryl organic compounds other than just benzyl halogens. It is within the scope of the present disclosure, for organic compounds comprising an electrophilic carbon atom and a halogen leaving group to be fluorinated by the methods of the disclosure. One aspect of the disclosure provides methods of introducing a fluorine atom onto an electrophilic carbon atom, comprising mixing an insoluble basic silver salt, an organic molecule containing a leaving group, an aqueous solution of hydrofluoric acid, and a polar solvent:water composition; incubating said mixture at a temperature of about 20° C. to about 35° C., thereby obtaining a fluorinated organic product.

1 - 7 . (canceled) 
     
     
         8 . A composition comprising an insoluble basic silver salt and silver fluoride, wherein the silver fluoride is disposed on a surface of the insoluble basic silver salt. 
     
     
         9 . The composition of  claim 8 , wherein the insoluble basic silver salt is silver oxide or silver carbonate. 
     
     
         10 . The composition of  claim 8 , wherein the composition results from the interaction of a  18 F-radiolabeled hydrofluoric acid at the concentrations encountered as the product of a cyclotron, comprising silver fluoride Ag 18 F and silver oxide, wherein the silver fluoride is disposed on the surface of the silver oxide.