Antibodies that bind both il-17a and il-17f and methods of using the same

Abstract

The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, as well as methods of using the same in inflammation.

1 . An isolated, cross-reactive monoclonal antibody that binds to both IL-17A (SEQ JD NO:2) and IL-17F (SEQ ID NO:4), wherein said antibody binds to a discontinuous IL-17F epitope comprising amino acid residues 105-109 and 147-152 of SEQ ID NO:4 and a discontinuous IL-17A epitope comprising amino acid residues 107-111 and 149-154 of SEQ ID NO:2; and wherein said antibody reduces the pro-inflammatory activity of both IL-17A and IL-17E. 
     
     
         2 . The antibody of  claim 1 , wherein said antibody is selected from the group consisting of a murine antibody, a chimeric antibody, a humanized antibody, and a human antibody. 
     
     
         3 . The antibody of  claim 1 , wherein said antibody is a single chain antibody. 
     
     
         4 . The antibody of  claim 1 , wherein said antibody is an antibody fragment. 
     
     
         5 . The antibody of  claim 4 , wherein the antibody fragment is selected from the group consisting of Fab, Fab′, F(ab′) 2 , and Fv antibody fragments. 
     
     
         6 . A composition comprising:
 the antibody according to  claim 1 ; and   a pharmaceutically acceptable vehicle, carrier, or excipient.