US2012177690A1PendingUtilityA1

Use of rapamycin derivatives in vasculopathies and xenotransplantation

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Assignee: SCHULER WALTERPriority: Mar 27, 1996Filed: Jan 24, 2012Published: Jul 12, 2012
Est. expiryMar 27, 2016(expired)· nominal 20-yr term from priority
Inventors:Walter SchulerHendrik SchuurmanGisbert WeckbeckerHans-Gunter Zerwes
A61P 35/00A61P 7/02A61P 9/00A61P 9/10A61P 37/00A61P 37/06A61P 43/00A61K 31/436A61K 31/435
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Claims

Abstract

Use of a rapamycin derivative of formula I as defined in the claims for preventing or treating vasculopathies and manifestations of xenotransplantation.

Claims

exact text as granted — not AI-modified
1 . A method for preventing or treating:
 vascular surgery induced neointimal proliferation and thickening and/or restenosis and/or vascular occlusion comprising administering to a subject in need thereof an effective amount of 40-O-(2-hydroxy)ethyl-rapamycin.   
     
     
         2 . A method according to  claim 1  for preventing or treating neointimal proliferation and thickening. 
     
     
         3 . A method according to  claim 1  for preventing or treating restenosis and/or vascular occlusion. 
     
     
         4 . A method according to  claim 1  for preventing or treating vascular occlusion. 
     
     
         5 . A method according to  claim 1 , wherein the vascular surgery is angioplasty.

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