Mixture of non-digestible oligosaccharides for stimulating the immune system

Abstract

Nutritional compositions with fucosyllactose and betagalactooligosaccharides for use in stimulation of the immune system. The composition is suitable for infants.

1 . A nutritional composition, comprising fucosyllactose and betagalacto-oligosaccharides, wherein the composition is not human milk. 
     
     
         2 . The nutritional composition according to  claim 1 , further comprising fructo-oligosaccharides and/or uronic acid oligosaccharides. 
     
     
         3 . The nutritional composition according to  claim 1 , further comprising fructo-oligosaccharides and uronic acid oligosaccharides. 
     
     
         4 . The nutritional composition according to  claim 1 , wherein the fucosyllactose comprises 2′-fucosyllactose. 
     
     
         5 . The nutritional composition according to  claim 1 , wherein the betagalacto-oligosaccharides have over 80% beta 1,4 and beta 1,6 linkages. 
     
     
         6 . The nutritional composition according to  claim 1 , comprising protein, digestible carbohydrates and fat, wherein protein provides 5 to 50%, digestible carbohydrates provide 15 to 85%, and fat provides 5 to 50% of calories based on total calories. 
     
     
         7 . The nutritional composition according to  claim 1 , comprising 0.07 to 1 wt. % of the 2′-fucosyllactose based on dry weight of the composition. 
     
     
         8 . The nutritional composition according to  claim 1 , wherein the composition is an infant formula. 
     
     
         9 . A method of providing nutrition comprising administering to a mammal in need thereof a composition according to  claim 1 . 
     
     
         10 . The method according to  claim 9 , wherein the mammal is a human infant, an elderly person, an oncology patient and/or a HIV patient. 
     
     
         11 . A method of stimulating the immune system, comprising administering to a mammal in need thereof a composition according to  claim 1 . 
     
     
         12 . A method of enhancement of a vaccination response in a mammal, comprising administering to the mammal a composition according to  claim 1 . 
     
     
         13 . A method of treatment and/or prevention of infections and/or disease, comprising administering to a mammal in need thereof a composition according to  claim 1 . 
     
     
         14 . A method of treatment and/or prevention of an immune disorder selected from the group consisting of asthma, allergy, atopic dermatitis, allergic conjunctivitis, dust mite allergy, urticaria and allergic rhinitis, comprising administering to a mammal in need thereof a composition according to  claim 1 . 
     
     
         15 . The nutritional composition according to  claim 2 , comprising 0.25 wt % to 15 wt % of the sum of betagalacto-oligosaccharides, fructo-oligosaccharides and uronic acid oligosaccharides, based on dry weight of the composition. 
     
     
         16 . The method according to  claim 11 , wherein the immune system stimulation comprises increasing Th1 response and/or increasing Th1/Th2 balance.